Therapeutic Applications of Dopamine D3 Receptor Function, 1st ed. 2023 New Insight After 30 Years Of Research Current Topics in Behavioral Neurosciences Series, Vol. 60

The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson?s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor.

The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.

Preface.- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction.- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System.- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function.- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression.- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target.- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease.- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor.- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders.- The Role of D3 Dopamine-Receptors in Nicotine Dependence:  A Synthesis of the Pre-Clinical and ClinicalLiterature.- The Dopamine D3 receptor in Food Addiction.- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia.- D3 receptors and Restless Legs Syndrome.- D3 receptors and PET imaging.

Examines the state of knowledge on the role of D3 dopamine receptor function in behavior & neuropsychiatric disorders Reviews the recent key research supporting D3 receptor targeting in the treatment of neuropsychiatric disorders Is of particular relevance to researchers and scholars with an interest in drugs for CNS disorders