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The Dopamine Receptors (2nd Ed., Softcover reprint of hardcover 2nd ed. 2010) The Receptors Series

Langue : Anglais

Coordonnateur : Neve Kim

Couverture de l’ouvrage The Dopamine Receptors

As sites of action for drugs used to treat schizophrenia and Parkinson?s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette?s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.

Historical Overview: Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation.- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor-Interacting Proteins.- Dopamine Receptor Oligomerization.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice.- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models.- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function.- In Vivo Imaging of Dopamine Receptors.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptor Subtypes in Reward and Relapse.- Dopamine Receptors and the Treatment of Parkinson’s Disease.- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Relies heavily on new knowledge The use of knock-out mice and subtype-selective drugs merit discussion in stand-alone chapters The field of G protein-coupled receptors has advanced significantly since the publication of the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors Key aspects of this advanced model are specifically addressed in new chapters on dopamine receptor-interacting proteins and on dopamine receptor oligomerization Includes supplementary material: sn.pub/extras

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Date de parution :

Ouvrage de 648 p.

15.5x23.5 cm

Sous réserve de disponibilité chez l'éditeur.

295,39 €

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