Understanding the Pandemic Pathophysiology, Transmission and Treatment of COVID-19

Langue : Anglais

Coordonnateurs : Chatterjee Shampa, Duarte Neto Amaro Nunes, Cascella Marco, Villapol Sonia, Viswanathan Anand, Ganesh Aravind, Lai Ching Lung, Remuzzi Giuseppe

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Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage, associated factors, and comorbidities that drive mortality. Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune response to the virus and its effect on various organs. It examines clinical cases based on an observations and postmortem studies. Other topics include the long-term effects of COVD-19, vaccines, and public health response.

Section 1: coronaviruses (incl SARS-CoV and MERS), the structure (sequence), mechanism of action 1. Origin of SARS-CoV-2 2. SARS-CoV-2: Insights into the genome structure 3. Mechanism of binding and infection: Role of the Spike Glycoprotein 4. ACE2 in SARS-CoV-2 infectivity 5. Population-Specific Polymorphisms and SARS-CoV-2 Infectivity 6. SARS-CoV-2, SARS-CoV, and MERS-COV: similarities and differences in origin and transmission Section 2: Immune Response to COVID-19 and its effects on various organs 7. Characterization of the immune response with viral attack 8. Immune Responses and COVID-19 severity 9. Seroconversion and Adaptive Immunity to COVID-19 10. Organ specific immune related changes with COVID-19 11. Blocking immune pathways in COVID-19 12. Immune Response in Fatal COVID-19 Section 3: “Clinical manifestations based on reports from clinical observations and postmortem studies 13. Postmortem Examination of COVID-19 Lungs and Heart 14. Renal Histopathological Analysis Kidney 15. Postmortem Neuropathology in COVID-19 16. Microcirculation Section 4: The blood vessels and COVID-19: Vascular dysfunction, coagulopathies 17. Vascular manifestations of COVID-19: endothelial dysfunction and damage 18. Vasculitis and proinflammatory cascades with COVID-19 19. D-dimer in systemic circulation and COVID-19 outcome 20. Hypercoagulability in COVID-19 Section 5: Neuro-COVID-19 and its long-term implications 21. COVID and the nervous system: Mechanisms and Consequences 22. Neuroinflammation with COVID-19: single cell and model studies 23. Neurologic and Psychiatric outcome in survivors Section 6: Should COVID-19 concern nephrologists? Why and to what extent?" 24. Mechanisms that drive in acute kidney injury with COVID-19 25. Models and cellular monolayers to study effect of SARS-CoV-2 on kidney 26. Renal Manifestations of COVID-19 in the Clinic Section 7: Long COVID-19 (long term effects summarizing of clinical reports in literature) 27. Long COVID or post-acute sequalae of COVID: An introduction 28. Mechanisms and Risk factors 29. Characterizing Long COVID-19: Lessons in the clinic 30. Risk factors and Management Section 8: The vaccines 31. COVID-19: The vaccine development strategies 32. mRNA vaccines: The new frontier 33. Safety and Efficacy: A comprehensive review Section 9: Public health handling (lessons from the US, EU, Brazil, China, India etc.) 34. US 35. EU 36. Brazil 37. China 38. India Section 10: From the Editors’ desk 39. The COVID-10 pandemic: Lessons Learnt 40. Current and Future Perspectives

Dr. Shampa Chatterjee received her PhD in Chemistry from the Indian Institute of Technology (Bombay) in 1997. Her research interests are in the field of reactive oxygen species (ROS) and redox biology as it relates to inflammation. Her lab studies the effect of ROS generated by the vascular wall in onset of inflammation. Toward this, work from her group shows that signals emanating from the wall of blood vessels are the earliest stimuli for the onset and amplification of inflammation. The topics addressed in this book are thus central to her research where she tries to unravel the balance between host defense and inflammation induced damage.

Currently, Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology (American Journal of Physiology: Lung Cellular and Molecular Physiology, Pulmonary Circulation and Jacobs Journal of Physiology). She has published more than 50 papers in peer reviewed journals. She has also received numerous awards such as the Carolin Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology in 2015.
Amaro Nunes Duarte-Neto is a Brazilian infectious disease physician and anatomical pathologist. He graduated in Medicine in 1999 from the University of Pernambuco and followed it with a medical residency in Internal Medicine and Infectiology at the University of São Paulo. His clinical path was as an intensivist and emergency care specialist. Besides his clinical responsibilities, he also studied infectious diseases and supervised students and residents. He completed his PhD on the pathology of severe leptospirosis followed by a medical residency in pathology at the A.C. Camargo Cancer Center in São Paulo. Since then, he has been dedicated to autopsy and infectious disease pathology such as COVID-19, yellow fever and other hemorrhagic fevers in Brazil, AIDS, tuberculosis, leprosy, fungal and parasitic diseases. He is currently a physician in the Depar

Discusses coronavirus and their similarities and differences in origin and transmission as well as a review of their structure and mechanisms of action
Examines the immune-inflammation responses to COVID-19 and the organ-specific impact of the disease
Covers vaccines and other treatment protocols and public health responses in various geographic locations