Nucleic Acid-Based Nanomaterials Stabilities and Applications

Nucleic Acid-Based Nanomaterials

Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies

Nucleic acids, the biomolecules that carry most of nature?s critical genetic information, are an omnipresent component of life on earth. Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more. Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials.

Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications. Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries. The result is an essential contribution to materials science in a variety of life-saving contexts.

Nucleic Acid-Based Nanomaterials readers will also find:

• Application-oriented structure that grounds general concepts in their specific instantiations
• Detailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and more
• A rigorous yet accessible approach suitable for both academia and industry

Nucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.

Preface xi

1 Introductions of Nucleic Acid-Based Nanomaterials 1
Shaojingya Gao and Yunfeng Lin

1.1 History of DNA-Based Nanomaterials - Design and Construction 3

2 The Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials 15
Xueping Xie

2.1 Introduction 15

2.2 Methods to Improve Stability 16

2.3 Conclusion and Recommendations 26

3 Framework Nucleic Acid-Based Nanomaterials: A Promising Vehicle for Small Molecular Cargos 37
Yanjing Li

3.1 Basis of FNAs as Potential Drug Carriers 38

3.2 Small-molecule Cargos 41

3.3 Merits of FNA Delivery Systems in Biomedical Application 46

3.4 Conclusions and Prospects 52

4 The Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Mitochondrial Dysfunction 61
Lan Yao and Tao Zhang

4.1 Introduction 61

4.2 Treatment Mechanisms in Mitochondrial Dysfunction 61

4.3 Nucleic Acid Nanomaterial-Based Delivery System in Mitochondrial Treatment 65

4.4 Challenges and Prospectives 71

5 Regeneration of Bone-Related Diseases by Nucleic Acid-Based Nanomaterials: Perspectives from Tissue Regeneration and Molecular Medicine 81
Xiaoru Shao

5.1 Introduction 81

5.2 The Development Process of Functional Nucleic Acid 82

5.3 Nucleic Acid-Based Functional Nanomaterials 84

5.4 Multiple Roles of Nucleic Acid-Based Functional Nanomaterials in Bone Tissue Repair and Regeneration 89

5.5 Conclusion and Perspectives 94

6 In Situ Fluorescence Imaging and Biotherapy of Tumor Based on Hybridization Chain Reaction 101
Ye Chen, Songhang Li, and Taoran Tian

6.1 Hybridization Chain Reaction 102

6.2 Nucleic Acid Detection 102

6.3 Protein Detection 107

6.4 Multiple Target Detection 109

6.5 HCR-Based Assembly Nanoplatforms 113

6.6 HCR-Based Tumor Biotherapy 115

6.7 Conclusion 116

7 Application and Prospects of Framework Nucleic Acid-Based Nanomaterials in Tumor Therapy 123
Tianyu Chen and Xiaoxiao Cai

7.1 Development of Nucleic Acid Nanomaterials 124

7.2 Properties and Applications of Nucleic Acid Nanomaterials 125

7.3 Conclusion 133

8 Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Endocrine and Metabolic Diseases 139
Jingang Xiao

8.1 Endocrine and Metabolic Diseases 139

8.2 Nucleic Acid Nanomaterials 141

8.3 Nucleic Acid and Drugs 141

8.4 Nucleic Acid Nanomaterials for Endocrine and Metabolic Diseases 144

8.5 Conclusion and Outlook 149

9 The Antibacterial Applications of Framework Nucleic Acid-Based Nanomaterials: Current Progress and Further Perspectives 161
Zhiqiang Liu and Yue Sun

9.1 Some Advantages of DNA Nanostructures in the Antibacterial Field 163

9.2 Application of 2D Nanostructures in the Antibacterial Field 164

9.3 Application of 3D DNA Nanostructures in the Antibacterial Field 166

9.4 Application of DNA Hydrogel Nanostructures in the Antibacterial Field 170

9.5 Challenges and Further Perspectives 172

10 Framework Nucleic Acid Nanomaterial-Based Therapy for Osteoarthritis: Progress and Prospects 181
Yangxue Yao, Hongxiao Huang, and Sirong Shi

10.1 Introduction 181

10.2 Pathology of OA 181

10.3 Risk Factors of OA 183

10.4 Challenges for OA Therapy 183

10.5 Nucleic Acid Nanomaterial-Based Therapy for OA 184

10.6 Conclusion and Prospects 194

References 195

Index 205

Yunfeng Lin, PhD, is a full professor at Sichuan University, China. He also obtained his PhD from Sichuan University in 2006. He is Vice-Director of West China Medical Center, Sichuan University, and Vice-Director of State Key Laboratory of Oral Diseases.

Shaojingya Gao, PhD, MSc, is a postdoctoral researcher in State Key Laboratory of Oral Diseases. She earned her MSc in 2019 and her PhD in 2022 from West China College of Stomatology in Sichuan University, China