Multifaceted Biomedical Applications of Graphene, 1st ed. 2022 Advances in Experimental Medicine and Biology Series, Vol. 1351

This book explains the fundamental characteristics and biofunctionality of graphene-based nanomaterials and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the chemical composition and physical properties of graphene and its derivatives as well as their potential toxicity and biosafety. Detailed attention is then devoted to the potential of multifunctional graphene-based nanomaterials (MFGNs) to direct the differentiation of stem cells into specific lineages and induce tissue regeneration. Here, individual chapters address the application of MFGNs for the purposes of neurogenesis, osteo- and chrondrogenesis, myogenesis, and wound healing. Subsequent sections focus on the capability of MFGNs as agents for drug delivery, bioimaging, theranostics, and therapeutics as well as their effectiveness as biomimetic platforms for nanobiosensors, biochips, medical devices, and dental applications. The book will beessential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel MFGN-incorporated composite materials and develop functional devices based on them.

I. Basic Features and Potential Toxicity of Graphene Family Nanomaterials.- Principles and Biomedical Application of Graphene Family Nanomaterials.- Differential Toxicity of Graphene Family Nanomaterials Concerning Morphology.- II. Graphene-based Nanomaterials as Scaffolds for Stem Cell Fate Modulation and Tissue Regeneration.- Graphene-based Materials for Efficient Neurogenesis.- Functional Graphene Nanomaterials-based Hybrid Scaffolds for Osteogenesis and Chondrogenesis.- Role of Graphene Family Nanomaterials in Skin Wound Healing and Regeneration.- III. Graphene as Agents for Drug Delivery, Bioimaging, Theranostics, and Therapeutics.-  Graphene-based Nanomaterials as Drug Delivery Carriers.- Graphene-based Nanomaterials for Biomedical Imaging.- Graphene - A Promising Theranostic Agent.- Graphene as Photo-thermal Therapeutic Agents.- IV. Graphene for Nanobiosensors, Biochips, and Antibacterial Agents.- Graphene for Nanobiosensors and Nanobiochips.- Antibacterial Activity of Graphene-based Nanomaterials.- Conclusions.- Reflections and Outlook on Multifaceted Biomedical Applications of Graphene.

Dong-Wook HAN, Professor, Department of Optics and Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Republic of Korea.

Suck Won HONG, Professor, Department of Optics and Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Republic of Korea.