Molecular Hematology (5^th Ed.)

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated

Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.

Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.

• Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies
• Illustrates the impact of molecular research on hematologic investigations and therapeutics
• Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders
• Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma
• Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools

Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Foreword

1 Beginnings: The Molecular Pathology of Hemoglobin

2 Stem Cells

3 The Genetics of Acute Myeloid Leukemias

4 Molecular diagnostics and risk assessment in myeloid malignancies

5 Molecular basis of acute lymphoblastic leukemia

6 Chronic Myeloid Leukemia

7 Myeloproliferative neoplasms

8 Lymphoma genetics

9 Molecular basis of chronic lymphocytic leukemia

10 The Molecular Biology of Multiple Myeloma

11 The Molecular Basis of Bone Marrow Failure Syndromes and Red Cell Enzymopathies

12 Anemia of chronic disease

13 Molecular Basis of Iron Metabolism

14 Hemoglobinopathies due to Structural Mutations

15 Molecular Coagulation and Thrombophilia

16 The Molecular Basis of Hemophilia

17 The Molecular basis of von Willebrand Disease

18 Platelet Disorders

19 The Molecular Basis of Blood Cell Alloantigens

20 Functions of Blood Group Antigens

21 Autoimmune hematologic disorders

22 Molecular Therapeutics in Hematology: gene therapy

23 Pharmacogenomics

24 Cancer stem cells

25 CAR-T cell therapy

DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.