Microfluidics-Aided Technologies Platforms for Next Generation Biological Applications

Langue : Anglais

Coordonnateurs : Bodas Dhananjay, Gajbhiye Virendra

Résumé
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Microfluidics-Aided Technologies: Platforms for Next Generation Biological Applications aims to provide comprehensive information of microfluidic technologies, their development and biomedical applications. The book provides the fundamentals of microfluidics and addresses the advances and challenges of microfluidic platforms for diagnostics, biological assays, cellular analysis, and drug delivery. Sections introduce micro-scale flow enabled systems, followed by discussions on applications in diagnostics, prognostics, and cellular analysis in the second and third section. The fourth section focuses on breakthroughs in microfluidics like 3D bioprinting, tissue-on-chip, organ-on-chip, and organism-on-chip. The last section provides insights on microfluidics and the study of plants and microbes.

This book offers researchers an interdisciplinary perspective towards biological problems. It is a resource for advanced undergraduate, graduate students, researchers and industry scientists interested in the emergence of advance techniques and next generation microfluidics-aided technologies for applications in the biomedical and medical research.

Section 1: Introduction to Micro-scale flow enabled systems 1. Fundamentals of Microfluidics 2. Mathematical modelling in microfluidics for biosystems 3. Breakthroughs and Current Limitations in microfluidic systems Section 2: Methods and Applications of Microfluidics - I 4. Microfluidic Systems in Prognostics and Diagnostics 5. Microfluidics in drug screening and drug delivery 6. Microfluidics assisted cell engineering and manipulation 7. Microfluidics assisted Cellular Analysis 8. Microfluidics in Bioimaging – in vivo and in vitro advancements Section 3: Methods and Applications of Microfluidics - II 9. Genetic sequencing and editing using microfluidics (system on chip approach) 10. Anaphylactic detection using microfluidic systems 11. Microfluidic systems for bacterial and fungal research 12. Microfluidics in studying disease biology and disease modelling in vitro 13. Microfluidics in bioanalytical chemistry Section 4: Breakthroughs in Microfluidics 14. Role of Microfluidics in 3D bioprinting 15. Tissue-on-Chip, Organ-on-chip and Organism-on-chip 16. Microfluidics in Regenerative medicine 17. Microfluidics in Protein engineering 18. Microfluidics-enabled Multi-omics analysis system Section 5: Microfluidics and its applications in Microbe and Plant study 19. Microfluidics assisted study of plant biomechanics 20. Plant-on-chip (root chips, shoot chips, apical chips) 21. Microfluidic device to study the effect of chemical and mechanical cues on cells 22. Investigating diatoms in a microenvironment using microfluidics

Dr. Dhananjay Bodas completed his doctoral research in the field of Microelectronics from the Department of Electronic Science, University of Pune in 2004. He is a recipient postdoctoral awards from the Defense ministry of France and the prestigious Alexander von Humboldt Foundation in 2004 and 2006, respectively. He is currently working as a Scientist E in the Nanobioscience Group at the Agharkar Research Institute in Pune, India. He works at the interface of microtechnology, surface chemistry, and application biology. Current areas of interest are understanding flows at microscale by fabricating devices using unconventional techniques and the development of ultra-sensitive and specific diagnostic platforms to detect pathogens and development of organ-on-chip platforms.
Dr. Virendra Gajbhiye has been working in the field of nanomedicine for the last 15 years. He has a doctoral degree (Ph.D.) in Pharmaceutical Science with post-doctoral research experience at University of Wisconsin-Madison and Oregon Health and Sciences University. Since 2013 he is working as a Scientist in Nanomedicine at Agharkar Research Institute, Pune, India. He has worked extensively with polymeric nanoparticles specially dendrimers and mesoporous silica nanoparticles. His research interest lies in Nanomedicine, Targeted drug and siRNA delivery, Biomedical application of dendrimers, Biomaterials unimolecular micelles and imaging, Multifunctional polymeric nanoparticles, Nanoparticles in tissue engineering.

Discusses the development of advanced techniques and methods for the diagnosis and treatment of various diseases
Discusses experimental approaches that facilitate the study of various aspects of life sciences
Presents biomaterial design strategies and recent breakthroughs for organ-on chip and organism on chip platforms
Summarize various polymers, techniques and types of microfluidic devices