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Medical and Health Genomics of South Asia Genomic and Precision Medicine in Clinical Practice Series

Langue : Anglais

Coordonnateurs : Kumar Dhavendra, Thangaraj Kumaraswamy

Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region.

Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

Section I: Basic human genetics and genomics 1. Population origin and variation of the South Asian peoples 2. Introduction to genomic and molecular biology 3. Microbial and Pathogenomics with reference to tropical infections 4. Pharmacogenetics and Pharmacogenomics including traditional/ indigenous herbal medicines 5. South Asia genomic heterogeneity in transplantation medicine 6. Genome databases and digital genomic healthcare Section II: Hereditary disorders of the South Asian subcontinent 7. Epidemiology of inherited disorders of India and regional nations 8. Heterogeneity of hereditary diseases in South Asia 9. Metabolic and mitochondrial diseases 10. Haemoglobinopathies and related inherited blood diseases 11. Neurogenetics/ Neuro-psychiatric diseases 12. Inherited cardiovascular diseases 13. Inherited eye diseases in South Asia 14. Inherited immune deficiency disorders 15. Familial and Inherited cancer 16. Rare genetic diseases Section III: Genomics of Infectious diseases 17. Malaria genomics and applications 18. Mycobacterial diseases genomics and Tuberculosis Including Leprosy 19. Leishmaniasis- the paradigm of tropical infectious disease 20. Viral diseases- HIV; Dengue; Chikangunia; Covid and others 21. Anti-microbial therapy- resistance; response; adverse drug reactions 22. Next generation drugs and vaccines Section IV: Environmental and Life style diseases 23. Complex genetic and genomic diseases in South Asia 24. Diabetes and related glycemic diseases 25. Coronary artery disease and Hypertension 26. Respiratory diseases- Bronchial asthma and High altitude living 27. Inflammatory/ Auto-immune diseases 28. Gastro-intestinal diseases including Hepato-biliary-pancreatic disorders 29. Mental health/ Neuro-psychiatric diseases 30. Regional and Occupational diseases Section V: Health genomics of the South Asia 31. The organisation and function of clinical genomics & genetic counselling 32. Genome laboratories and Genome database systems 33. Fertility and Assisted Reproduction 34. Fetal Medicine and Newborn screening 35. Genetic and genomic education & training 36. Public and Population health genomics of the Indian subcontinent 37. Human genomics in Sri Lanka- from clinics to community 38. Clinical and Molecular genetic initiatives in Nepal 39. Medical and population genomics in Pakistan 40. Medical genetics and genetic counselling in Bangladesh 41. Human genomic disease specific database development- the model of the Global Globin database 42. Lay people & Public awareness and outreach 43. Religion and socio-cultural perspectives 44. Ethical, Legal and Social Issues (ELSI) 45. Glossary

Professor Dhavendra Kumar is a Visiting Professor within the Genomic Policy Unit, Faculty of Life Sciences and Education, at the University of South Wales; and a Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George’s Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with a MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).
Dr. Kumaraswamy Thangaraj is Deputy Director at the Centre for Cell and Molecular Biology & Director, Centre for DNA Fingerprinting and Diagnostics in Hyderabad, Telangana, India. His major research interest sits in the fields of human origins, health and disease. He is interested in understanding the complex origin and affinities of Indian populations, using the genomics variations of contemporary populations and ancient biological remains. He is also interested in understanding the impact of endogamy on health and disease of South Asians. Dr. has published widely in such peer reviewed journals as Nature, the American Journal of Human Genetics, Molecular Biology and Evolution, and Current Biology.
  • Provides a detailed examination of medical genomics as applied in South Asian populations, including current and origin populations
  • Considers genetic and genomic epidemiological approaches for studying and treating genetic, infectious, and lifestyle diseases across South Asia, with an emphasis on heterogeneity
  • Highlights population health challenges with global prevalence
  • Acts as a practical reference for genomic education and implementation in the region
  • Features contributing experts from various South Asian nations and beyond

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