Lifestyle Epigenomics

Langue : Anglais

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Lifestyle Epigenomics, a new volume in the Translational Epigenetics series, comprehensively details the interplay between lifestyle factors and epigenetic modifications associated with the onset of noncommunicable diseases and aging, shedding light on potential preventive and therapeutic strategies for disease from an epigenomics perspective. Here, more than 35 international experts in the field consider how lifestyle choices or habits can condition or prevent disease, along with tools for new research, from bioinformatics methodology to non-invasive sampling. Early, foundational chapters are followed by all-inclusive sections on epigenetic machinery in health and disease; dietary factors and epigenetics; adiposity and physical activity and epigenetics; psychological stress, social environment, toxics and contaminants exposure effect on epigenetics; and transgenerational and childhood epigenetics. To support understanding, each chapter includes a summary and key points lists, terms and definition, as well as research case studies outlining core components of recent studies, detailing their conditions, research techniques involved, and outcomes.

SECTION I: Introduction 1. Introduction to lifestyle-relate epigenetic changes in disease aetiology 2. Lifestyle factors in aging and non-communicable disease SECTION II: Epigenetic machinery in health and disease 3. Epigenetic regulation in health and disease 4. Epitranscriptomics in health and diseases 5. Sirtuins in health and diseases. 6. Epigenetic mechanisms and exosomes in the effect of lifestyle factors on health 7. Epigenetic Clock and leukocyte telomere Length 8. Mitochondrial DNA Methylation and Human Diseases 9. Gut Microbiota and epigenetic mechanisms 10. Bioinformatics tools to study epigenetic mechanisms and lifestyle 11. Liquid Biopsy and epigenetic biomarkers for evaluation lifestyle factors effects on health 12. Current perspectives on possible Epigenetic therapy SECTION II: Dietary factors and epigenetics 13. Healthy diets and epigenetic regulation 14. Vitamin D and vitamin B12 and epigenetic mechanisms in health a disease 15. NNMT and epigenetic mechanisms in health and disease 16. Dietary phytochemicals and epigenetic mechanisms in health and disease 17. Energy restriction and ketogenic diets 18. Diet, gut microbiota and epigenetics interplaying in health and disease SECTION III: Adiposity and Physical activity and epigenetics 19. Obesity and epigenetics. Matthias Blüher 20. Impact of physical exercise on epigenetics and metabolic disorders 21. Physical activity, epigenetics and longevity 22. Epigenetics impact of exercise on cognitive impairment and memory 23. Physical activity and epigenetic regulation in depression 24. Exercise and epigenetic regulation in cancer survivors SECTION IV: Psychological stress, social environment, toxics and contaminants exposure effect on epigenetics 25. Alcohol abuse and epigenetic regulation of human health 26. Drug abuse and epigenetic regulation of human health 27. Air pollution and epigenetic regulation of human health 28. Endocrine disruptors and epigenetic regulation of human health 29. Micro(nano)plastics and epigenetic regulation of human health 30. Epigenetic changes induced by stress exposure and metabolic diseases 31. Social adversity and epigenomics SECTION V: Transgenerational and childhood epigenetics 32. Father lifestyle and offspring’s epigenetic regulation 33. Mother lifestyle and offspring’s epigenetic regulation 34. Breastfeeding and epigenetic regulation of human health 35. Childhood lifestyle and epigenetic regulation of human health

Dr Crujeiras’ academic and professional trajectory has focused on translational research following a complex training that encompassed basic and clinical research. First finishing her degree in Biology at the University of Santiago de Compostela, Spain (July 2002), she then completed her PhD at the University of Navarra (July 2008) in the Nutrition field, implementing a successful treatment to fight obesity and its associated diseases. Later (October, 2008) she joined the Department of Molecular and Cellular Endocrinology at the Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) with a postdoctoral research position. There, she established a new research line on the association between obesity and cancer. From September 2011 to December 2013, in the context of a second postdoctoral stay, she joined the Cancer Epigenetics and Biology Program (PEBC) at Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

Currently she leads the Epigenomics in Endocrinology and Nutrition research group at Health Research Institute of Santiago de Compostela (IDIS), after getting the prestigious position of Senior Researcher recognized by the Spanish Ministry of Science and Innovation in 2018.

Fully examines how lifestyle choices or habits can condition aging
Considers epigenetic mechanisms involved in the promotion of health and disease, as well as developmental and physiological processes
Details tools to evaluate and research epigenetic mechanisms influenced by lifestyle factors
Features chapter summaries, key term definitions, and research case studies to reinforce understanding and support new research
Includes chapter contributions from international experts in the field