Immunodominance: The Choice of the Immune System

This very first handbook on the topic summarizes the current concepts and brings together in one volume the critical arguments concerning the mechanisms relevant to immunodominance. In invited chapters written by the leaders in the field, the mechanisms whereby the immune system chooses the parts of a recognized pathogen in order to start the immune response are explained and the variety of biologic processes are identified that contribute to that choice. From the contents: Mechanics of antigen processing. Proteosome specificity and immuno-proteosomes. Effect of the T cell repertoire on dominance. Effects of pathogens on the immune response.

MECHANICS OF ANTIGEN PROCESSING Class I (Rock, USA, Neefjes, Netherlands) Class II (Unanue, USA) Impact of MHC on epitope selection (Sette, USA) PROTEOSOME SPECIFICITY AND IMMUNO-PROTEOSOMES DRIPS (Yewdell, Bennick, USA) Classical processing (Cresswell, USA) EFFECT OF THE T CELL REPERTOIRE ON DOMINANCE Innate repertoire (Rocha, France) Selected repertoire (Sherman, USA) Thymic Development (Zuniga, Pflucker, Canada, Robey, USA, Fowlkes, USA) Regulatory T cells (Paul, USA, O'Garra, UK) EFFECTS OF PATHOGENS ON THE IMMUNE RESPONSE Herpes viruses (Rickenson, UK, Moss, Australia, Hill, USA) HIV (McMichael, UK, Gotch, UK, Tackiguchi, Japan) Influenza (Doherty, Austalia, Braciale, US) Listeria (Harty, USA, Pamer, USA) TB/Leprosy (Flynn, USA, Bloom, USA) Malaria (Hill, UK, Nussenswieg, USA) Generation of Memory T cells (Woodland, USA, Heath, Australia) HTLV (Bangham, UK) Hepatitis (Chisari, USA)