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Porous Silicon for Biomedical Applications (2nd Ed.) Woodhead Publishing Series in Biomaterials Series

Langue : Anglais

Coordonnateur : Santos Hélder A.

Couverture de l’ouvrage Porous Silicon for Biomedical Applications

Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy.

Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry.

This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more.

With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.

Introduction H.A. SantosPart I: Fundamentals of porous silicon for biomedical applications 1. Thermal stabilization of porous silicon J. Salonen and E. Mäkilä 2. Thermal properties of nanoporous silicon materials N. Koshida 3. Photochemical and nonthermal chemical modification of porous silicon K.W. Kolasinski 4. Protein-modified porous silicon optical devices for biosensing M. Terracciano, C. Tramontano, R. Moretta, B. Miranda, N. Borbone, L. De Stefano, and I. Rea 5. Biocompatibility of porous silicon I.S. Naiyeju and L.M. Bimbo

Part II: Porous silicon for bioimaging and biosensing applications 6. Optical properties of porous silicon materials V. Torres-Costa and R.J. Martín-Palma 7. Radiolabeled porous silicon for nuclear imaging and theranostic applications M. Sarparanta and A.J. Airaksinen 8. Porous silicon for targeting microorganisms: Detection and treatment N. Massad-Ivanir, S. Arshavsky-Graham, and E. Segal 9. Porous silicon biosensors for DNA sensing G.A. Rodriguez, J.L. Lawrie, R. Layouni, and S.M. Weiss 10. Near-infrared imaging for in vivo assessment of porous silicon-based materials B. Xia, J. Li, and Y. Gao 11. Porous silicon-based sensors for protein detection E.E. Antunez, M.A. Martin, and N.H. Voelcker

Part III: Porous silicon for drug delivery, cancer therapy, and tissue engineering applications 12. Nanoporous silicon to enhance oral delivery of poorly water-soluble drugs H.B. Schultz, P. Joyce, C.A. Prestidge, and T.J. Barnes 13. Porous silicon for tumor targeting and imaging J.-H. Park, M. Jeong, and H. Kim 14. Porous silicon-polymer composites for cell culture and tissue engineering S.J.P. McInnes, R.B. Vasani, N.K. McMillan, and N.H. Voelcker 15. Porous silicon and related composites as functional tissue engineering scaffolds N.K. McMillan and J.L. Coffer 16. Porous silicon in photodynamic and photothermal therapy L.A. Osminkina and M.B. Gongalsky 17. Porous silicon microneedles and nanoneedles for biomedical applications C. Chiappini 18. Porous silicon materials for cancer and immunotherapy F. Fontana, Z. Liu, J. Hirvonen, and H.A. Santos

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.
  • Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material.
  • Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings.
  • Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.