Surgical Research in Implant Dentistry, 1st ed. 2023

This book explores, in a comprehensive and systematic manner, Surgical Research methodologies to the design and development of investigational studies in the field of implant-based oral rehabilitation. Such studies are linked in a chain binding in vitro, in vivo, ex vivo, and digital evaluations. An ambitious objective consists in exposing how investigators can generate and deliver knowledge by capturing synergy coming from preclinical and clinical trials. Accordingly, throughout the book, translational aspects are closely scrutinized. The opening chapters consider materials, methods and procedures for preclinical and clinical studies in which approaches and models are extensively described. The focus then moves to the process by which application of histology, biomechanics, biomarkers, cellular/molecular biology, and imaging technologies lead to new results and consequently novel treatment concepts in implant dentistry, implant borne prosthetic rehabilitations and the replacement or regeneration of tissues. Finally, the exciting opportunities afforded by the digital world are addressed. This book shall be a valuable resource and time-saving tool for a wide audience of researchers, students, practitioners, and academics.

1. The method sets the tone.- 2. Preclinical studies design and place of rodents .- 3. Preclinical studies design and place of rabbits .- 4. Preclinical studies design and place of swine .- 5. Preclinical studies in the canine model .- 6. Preclinical studies design and place of caprine and ovine.- 7. Clinical investigations in implant dentistry:experimentation versus observation and the future of merging data.- 8. Translational aspects in living mammalian organisms.- 9. Biomechanics of the radicular component of endosteal implants.- 10. Radiographic imaging in implant dentistry.- 11. Biological events at the interface between the radicular part of the implant and bone.- 12. Mechanics of the implant-abutment-connection.- 13. Mechanics of the prosthetic rehabilitations.- 14. Imaging of non resorbable bone substitutes.- 15. Biology of low-substitution bone substitutes.- 16. Imaging of resorbable bone substitutes .- 17. Biology of resorbable bone substitutes.- 18. Membranes and soft tissues enhancers.- 19. Biomarkers for implant dentistry studies.- 20. Computer-Assisted Implant Dentistry.- 21. Insight into statistical procedure.

Michel M. Dard, DDS, MS, PhD, was trained in dentistry and oral medicine in France (Universities of Bordeaux and Nantes) and at New York University, College of Dentistry, New York, USA. He is currently the Senior Director for Continuing Education and Clinical Development at Vizstara, New Jersey, USA. He served during 20 years successively as the Head of Preclinical Research, Head of Surgical and Clinical Science and Global Medical Director at the Straumann Group, Basel, Switzerland. Prior to this he was the Director of Oral and Cranio-Maxillo-Facial R&D at Biomet-Merck, Darmstadt, Germany. Dr. Dard’s fields of expertise include research and innovation management and administration, surgical methodology, surgical procedures in implant dentistry and periodontology, novel materials and medical devices, translational and precision dental medicine. He is a member of several international societies (IADR, ITI) and served for more than a decade as an expert at the French NIH (INSERM, Paris, France) and the Directorate for Research and Innovation of the European Union Commission (Brussels, Belgium). He is an Adjunct Associate Professor of Dental Medicine at Columbia University, New York, USA.

He holds several patents and is the author of more than 170 international peer-reviewed original articles, book chapters, monographs, reviews, and editorials.

He lectures globally at most noticeable offline and online international congress, symposiums, University seminars and before scientific societies on medical devices, biomaterials, tissues regeneration, implant dentistry and surgical & oral rehabilitation science.

Examines methodological approaches to the design and development of investigational studies...

Closely scrutinizes translational aspects

Includes consideration of the opportunities afforded by the digital world