Sepsis and Multiple Organ Dysfunction : A multidisciplinary approach

Sepsis and the multiple organ dysfunction that results from it is one of the commonest causes of death in the ICU. The last decade has seen an explosion in the understanding of the pathophysiology of sepsis, and progress in critical care medicine has allowed patients to be kept alive long enough for these new technologies to be utilized. This volume aims to be the definitive, gold-standard text on sepsis and multiple-organ dysfunction. It is comprehensive and thoroughly referenced : the one text in which all current knowledge on this important topic is brought together. The book is written by a team of international contributors, overseen by an internationally acclaimed editorial team. It effectively summarises the knowledge from all disciplines. Features : comprehensive, fully referenced source, multi-disciplinary contributions from world experts, outstanding world expert as main editor, academic and totally up-to-date, knowledge from all disciplines is summarised

1. Introduction and Epidemiology: Historical Perspective Terminology and Conceptual Challenges Multiple Organ Dysfunction: an Introduction MODS Following Trauma MODS in the Septic/Inflammatory Patient MODS in Children. Overview of Hypotheses and Putative Factors Infection, Sepsis and Septic Shock Pathophysiology Mediator Response Metabolic Response in the Critically Ill Ischaemia-Reperfusion Injury Coagulation Abnormalities in Sepsis Endothelial-Neutrophil Interactions The Gut Origin Hypothesis of Multiple Organ Dysfunction Effect of Hemorrhage on Immune and Inflammatory Response The Two-Hit Model of Multiple Organ Dysfunction. Molecular Mechanisms Molecular Mechanisms - an Overview Apoptosis and Organ Injury Heat Shock Proteins Biologic Variation and Genetics in the Inflammatory Response. Scoring Systems and Diagnosis Clinical and Physiologic Scoring Systems for Sepsis and Organ Dysfunction Risk Stratification and Outcome Inflammatory Serum Markers in Organ Dysfunction. Management Principles and Approaches Evidence-Based Critical Care Medicine Prevention of Organ Injury and MODS Principles of Fluid and Inotropic Resuscitation Controversies in Resuscitation Concepts in Hemodynamic Support Is Supranormal Oxygen Delivery Beneficial? Pro and Con Gastric Tonometry is ready for Widespread Clinical Use: Pro and Con Base Excess and Serum Lactate as Monitors of Resuscitation Nutritional Support Current and Future Antimicrobial Strategies and Antibiotic Resistance Selective Digestive Tract Decontamination Is Effective In Improving Outcomes: Pros And Cons Sepsis: Principles of Management Empirical Laparotomy In The Patient With Occult Sepsis Is No Longer Necessary: Pro And Con Status of the Open Abdomen in Patients with Uncontrolled Abdominal Sepsis Immunotherapy (Principles and Current Status) Immunotherapy - New Agents Septic Shock: What's New. Organ Systems and Their Supportive Care - The Lung Definitions and Pathophysiology of ARDS Nosocomial Pneumonia Pulmonary Support New Treatments for ARDS Liquid Ventilation for Adult Respiratory Failure - The Kidney Pathogenesis of Acute Renal Failure: the role of sepsis Renal Replacement and Support - Liver and Intestine Management of Acute Liver Failure Gut Barrier Failure - Heart Myocardial Dysfunction in Sepsis Hematologic Failure Central Nervous System Dysfunction in Sepsis - Intensive Care Issues Pharmocokinetics in the Critically Ill Sedation, analgesia and muscle relaxation in the intensive care unit Abdominal Compartment Syndrome in the Intensive Care Unit Patient Issues in Cost Effectiveness Withdrawal of Life Support Future [Editorial Discussion]

Surgeons, trauma and intensive care specialists