Principles of Molecular Probe Design and Applications, 1st ed. 2023

This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.

Chapter 1: Overview of the fundamentals of chemistry for molecular probe design.- Chapter 2: Principles for the design of fluorescent dyes.- Chapter 3: Principles for the design of PET probes.- Chapter 4: Principles for the design of MRI probes.- Chapter 5: Solid-phase chemistry.- Chapter 6: Construction of molecular probes and imaging applications

Wellington Pham received a Ph.D. degree in Medicinal Chemistry from the University of Toledo. His postdoctoral training focused on PET chemistry at The Crump Institute for Molecular Imaging, UCLA Medical School, followed by two postdoctoral trainings in molecular imaging at the Center of Molecular Imaging Research and the Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School. Currently, he is Professor of Radiology at Vanderbilt University Medical Center and holds joint appointments in the Departments of Biomedical Engineering, Vanderbilt Ingram Cancer Center, and Vanderbilt Brain Institute. He served on several steering committees and conference organizers on molecular imaging and molecular probes and a recipient of the Distinguished Investigator Award of the Academy for Radiology & Biomedical Imaging Research (2019). His research interests include the discovery of biomarkers and imaging probes, combined with delivery technologies dedicated to cancer and Alzheimer’s disease, and he has published nearly 150 publications, including peer-reviewed articles, book chapters, conference abstracts/proceedings, editorials, and patents on these subjects. His research has been funded by NIH, DOD, VA grants, and ADEKA Corporation.   

Covers the design and applications of probes that are used in all three key imaging modalities Describes various schemes for the synthesis of imaging agents applicable to preclinical animal models and clinical work Classifies probe design to the simplest pedagogical methods to promote self- and cross-disciplined training