Paraproteinemia and Related Disorders, 1st ed. 2022

This book presents paraproteinemia and the highly complex scientific information behind it to clinicians in a way they can understand and, ultimately, apply to their diagnostic and treatment practices. Paraproteinemia or dysproteinemia is characterized by the overproduction of an immunoglobulin by clonal expansion of cells from the B cells lineage which includes the plasma cells. The resultant monoclonal protein can be composed of the entire immunoglobulin or of its components. The identification and categorization of the different representatives of this group of disorders have traveled a long distance, but despite its high prevalence there is surprisingly limited evidence, in some areas, to guide the best clinical practice both at the time of diagnosis and during follow up. This book seeks to fill that gap.

The book is divided into three sections, introductory chapters, disease entities and experimental therapies. The text guides clinicians through these diseases and disorders. The group of renal diseases attributed to deposition of monoclonal immunoglobulins or their components are arranged as one disease category in order to simplify the understanding of these complicated diseases in plasma cell dysplasia. In emulation of this practical approach, at a larger scale, the volume editors and chapter authors attempt to encompass the whole spectrum of the paraproteinemias in this text. This will have the dual benefit of offering the audience a panoramic view of this group of disorders and simultaneously keeping them focused on its individual representatives. There have been many recent advances in diagnosis, risk stratifications, and management of many members of this group of diseases and they are explored in depth here.

This is an ideal guide for rheumatologists, hematologists, nephrologists, immunologists, oncologists, and relevant trainees caring for patients with paraproteinemia and related disorders.

Gaafar Ragab graduated from the Faculty of Medicine, Cairo University, 1976, where he got his degrees in Internal Medicine: MSc 1980, and PhD, 1985. He served his faculty as a Resident, Assistant Lecturer (1980), Lecturer (1985), Assistant Professor (1990), and Professor (1995) till now. He spent a sabbatical year 1989 at the UAB, USA, in the Department of Clinical Immunology and Rheumatology. He headed the Clinical Immunology and Rheumatology Unit affiliated to the Internal Medicine Department (2010–2013). He was Chief of the Internal Medicine Department’s Research Committee (1995–2013). He is Fellow of the American College of Rheumatology (ACR) since 1989. He co-founded the Egyptian Society of Immunology and Rheumatology (EGYSIR) which he headed as its President from 2010 to 2013. He was chosen as President of the Egyptian League Against Rheumatism (ELAR) annual meeting 2013. He is a member of the Advisory Board of the Egyptian Society of Internal Medicine (ESIM) and its journal and served as President of ESIM annual meeting, Cairo, 2014. He is member of the editorial board of the Journal of Advanced Research (JARE). He is currently the Chief Research Officer of New Giza University, Egypt.

Dr. Ragab co-edited "The Microbiome in Rheumatic Diseases and infection" by Springer 2018 and "Precision Anticoagulation Medicine: A Practical Guide" by Springer 2020. 

He also authored nine book chapters in in textbooks by international publishers. 

He served as a reviewer for many medical journals and publishing firms..

Dr. Ragab received:

- The prize of honor, Cairo University, for Distinguished Achievements in 2019.

- Prof. Dr. Ekram Abdel-Salam 2016 Prize, presented by Cairo University, for best research on Medical genetics. .

He is also member of:

- The International Study Group of Extrahepatic Manifestations Related to Hepatitis C Virus infection (ISGEHCV).

- The Egyptian National Committee for the

First text to deal with this group of diseases and disorders collectively as one class

Multi-author text by world-class experts from all over the globe

Combines chapters dealing with established disease entities and exploring uncharted areas