Nitric Oxide in Bone and Joint Disease Postgraduate Medical Science Series

Nitric oxide research has emerged as one of the most important areas in bone and joint diseases. First published in 1998, this book draws together knowledge on the actions of this mediator and its role in such common diseases as arthritis and osteoporosis. It introduces the basic biology and biochemistry of nitric oxide, the immune response and bone biology. It reviews in depth the facts we know today and the future promise of this exciting area of research. The book will give scientists and clinicians a unique insight into this increasingly important area. It also emphasises potential treatments which exploit our understanding of the role of nitric oxide in bone and joint disease.

Foreword Julia M. Polak; Part I. Nitric Oxide and Cytokines: An Introduction: 1. A brief overview of the biology of nitric oxide P. Vallance and S. Moncada; 2. Nitric oxide and immune responses I. B. McInness and F.Y. Liew; 3. Bone biology and pathophysiological mechanisms of bone disease R. G. G. Russell, P. Croucher, B. Oyajobi, S Rahman, M. Rogers and A. Scutt; Part II. Nitric Oxide in Arthritis: 4. Nitric oxide and blood flow in arthritis J. C. Lockhart, L. McMurdo and W. R. Ferrell; 5. Effects of nitric oxide synthase inhibitors in experimental models of arthritis C. H. Evans and M. Stefanovic-Racic; 6. Nitric oxide and prostaglandin interactions in acute and chronic inflammation D. Salvemini; 7. Nitric oxide and cartilage matrix turnover M. Cao, H. J. Hauselmann, M. Stefanovic-Racic and C. H. Evans; 8. Nitric oxide production in human inflammatory arthritides N. Miyasaka and Y. Hirata; 9. The complex influences of reactive oxygen species on rheumatoid erosions and synovitis J. M. Kanczler, T. Sahinoglu, C. R. Stevens and D. R. Blake; Part III. Nitric Oxide, Bone Cell Function and Osteoporosis: 10. Nitric oxide and osteoblast function F. J. Hughes, L. D. K. Buttery, M. V. J. Hukkanen and J. M. Polak; 11. Nitric oxide as a mediator of cytokine effects on bone S. H. Ralston; 12. The osteoclast, bone homeostasis and postmenopausal osteoporosis L. Mancini, N. Moradi-Bidhendi and I. MacIntyre; Part IV. Nitric Oxide and Mechanical Factors: 13. Modulation of bone blood flow by nitric oxide I. D. McCarthy; 14. Fluid shear stress T. N. McAllister and J. A. Frangos; 15. Mechanical strain-associated nitric oxide production by bone cells A. A. Pitsillides and L. E. Lanyon; 16. The response of bone and bone cells to mechanical stimulation T. J. Chambers, J. W. M. Chow, S. Fox, R. L. Howard, C. J. Jagger, J. M. Lean, F. T. Mitchell and R. Smalt; 17. Aseptic loosening of total hip prostheses S. A. Corbett, M. V. J. Hukkanen, S. P. F. Hughes and J. M. Polak; Index.

Nitric oxide research has emerged as one of the most important and new areas in bone and joint diseases. This book is the first one to draw together current knowledge on the actions of this mediator and its role in such common diseases as arthritis and osteoporosis. The book will give scientists and clinicians a unique insight into this increasingly important area. It also emphasises potential new treatments which exploit our understanding of the role of nitric oxide in bone and joint disease.