Myelodysplastic/Myeloproliferative Neoplasms An Atlas of Differential Diagnosis

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) is a challenging subset of neoplastic diseases of the blood and bone marrow. However, dynamic progress in array technologies and next-generation sequencing has provided new insights into the molecular pathogenesis of MDS/MPN. This practical atlas focuses on the differential diagnosis of these neoplasms, covering diagnosis and management, the diagnostic problems of MDS/MPN and differentiation from MPN or MDS, as well as diagnostic problems of initial MPN stages. Chapters feature up to date clinical guidelines and contemporary synthesis of the current state of the art in MDS/MPN diagnosis.

Problems and pitfalls regarding differentiation of MDS, MDS/MPN, and MPN. Overview of MDS. Diagnostic problems of initial MDS. MDS with unilineage and multilineage dysplasia. MDS with fibrosis vs. early primary myelofibrosis (PMF). MDS with 5q- vs. ET. Overview of MDS/MPN. Diagnostic problems of MDS/MPN and differentiation from MPN or MDS. CMML vs. Atypical CML. RARS-T vs. PMF, PV, ET. MDS/MPN,U vs. MPN-U. Acute panmyelosis with myelofibrosis vs. PMF, post PV and post ET MF. Overview of MPN. Diagnostic problems of initial MPN stages. ET vs. prefibrotic/early PMF and masked PV. PV with (initial) fibrosis vs. post PV-MF. PMF vs. post PV and post ET-MF. Progression in MPN – MDS-like and blast phase.