MRI of Short- and Ultrashort-T2 Tissues, 2023 Making the Invisible Visible

This book comprehensively covers ultrashort echo time (UTE), zero echo time (ZTE), and other magnetic resonance imaging (MRI) acquisition techniques for imaging of short and ultrashort-T2 tissues. MRI uses a large magnet and radio waves to generate images of tissues in the body. The MRI signal is characterized by two time constants, spin-lattice relaxation time (T1) which describes how fast the longitudinal magnetization recovers to its initial value after tipping to the transverse plane, and spin-spin relaxation time (T2) which describes how fast the transverse magnetization decays. Conventional MRI techniques have been developed to image and quantify tissues with relatively long T2s. However, the body also contains many tissues and tissue components such as cortical bone, menisci, ligaments, tendons, the osteochondral junction, calcified tissues, lung parenchyma, iron containing tissues, and myelin, which have short or ultrashort-T2s. These tissues are ?invisible? with conventional MRI, and their MR and tissue properties are not measurable. UTE and ZTE type sequences resolve these challenges and make these tissues visible and quantifiable.

This book first introduces the basic physics of conventional MRI as well as UTE and ZTE type MRI, including radiofrequency excitation, data acquisition, and image reconstruction. A series of contrast mechanisms are then introduced and these provide high resolution, high contrast imaging of short and ultrashort-T2 tissues. A series of quantitative UTE imaging techniques are described for measurement of MR tissue properties (proton density, T1, T2, T2*, T1p,magnetization transfer, susceptibility, perfusion and diffusion). Finally, clinical applications in the musculoskeletal, neurological, pulmonary and cardiovascular systems are described.

This is an ideal guide for physicists and radiologists interested in learning more about the use of UTE and ZTE type techniques for MRI of short and ultrashort-T2 tissues.

Part I: UTE MRI - Data Acquisition.- Basic Principles of MRI.- An Introduction to UTE MRI.- 2D UTE MRI.- 3D UTE MRI.- ZTE MRI.- PETRA MRI.- SWIFT MRI.- WASPI MRI.- Hybrid 3D UTE (Stack of STAR, AWSOS).- Cartesian Variable TE MRI.- Part II: UTE MRI - Contrast Mechanisms.- UTE with Echo Subtraction.- UTE with on/off Resonance Saturation.- UTE with Adiabatic Inversion (Single IR, Dual IR, Double IR, IR Fat Sat, DESIRE, STAIR).- UTE with Water Excitation.- UTE Fat/Water Imaging (UTE IDEAL, UTE Single Point Imaging).- UTE Spectroscopic Imaging.- Pulse Sequence as Tissue Property Filters.- Clinical Use of MASTIR Pulse Sequences.- Part III: UTE MRI – Quantification.- UTE T1 Quantification.- UTE T2* Quantification.- UTE Looping Star T2* Quantification.- UTE T1Quantification.- UTE Proton Density Quantification.- UTE Magnetization Transfer Imaging.- UTE Quantitative Susceptibility Mapping.- UTE Perfusion.- UTE Diffusion.- UTE with deep learning for fully automated segmentation and quantitativemapping.- Part IV: UTE MRI – Applications.- UTE T2* in Osteoarthritis.- UTE MRI Biomarker Panel in Osteoarthritis.- UTE Porosity Index and Suppression Ratio in Osteoporosis.- UTE Bound Water and Pore Water in Osteoporosis.- UTE MRI Biomarker Panel in Osteoporosis.- UTE MRI in the Spine.- UTE MRI in Tendinopathy.- UTE MRI in Psoriatic Arthropathy.- UTE MRI in Hemophilia Arthropathy.- UTE MRI in Temporomandibular Disorders.- UTE MRI in Multiple Sclerosis.- UTE MRI in Traumatic Brain Injury.- UTE MRI in the Lung.- UTE MRI in the Liver.- UTE MRI in cerebral aneurysm and coil embolization.- UTE MRI in Vascular Calcification.- UTE MRI in Cryotherapy.- UTE MRI of iron nanoparticles.- UTE in PET/MRI.- UTE MRI in “CT-like” bone imaging.- Challenges and future directions in UTE imaging.

Dr Jiang Du is a physicist who is Professor of Radiology and Director of the Ultrashort Echo Time (UTE) Imaging Lab at the University of California, San Diego (UCSD). His research focuses on the development of magnetic resonance imaging (MRI), especially UTE MRI of short and ultrashort-T2 tissues such as cortical bone, tendons, ligaments, menisci, iron containing tissues and myelin. He has published over 200 papers and mentored more than 100 trainees. Currently,he is a principal investigator for three NIH RO1 grants and one VA merit grant to study osteoarthritis (OA), osteoporosis (OP), Alzheimer’s disease (AD), and traumatic brain injury (TBI). He has served on many academic organizations and review committees, including study sections for the National Institute of Health (NIH), Department of Defense (DOD), and Radiological Society of North America (RSNA). He has won numerous awards including the RSNA Research Scholarship, the American Heart Association (AHA) Young Investigator Award, the International Society of Magnetic Resonance in Medicine (ISMRM) Outstanding Teacher Award, the International Skeletal Society (ISS) Excellence Award, and the Academy for Radiology & Biomedical Imaging Research (ARBIR) Distinguished Investigator Award. Dr Du is Fellow of the ISMRM and American Institute for Medical and Biological Engineering (AIMBE).

Dr Graeme Bydder is a radiologist who began clinical MRI in 1981 and has continued to the present day. He was a joint author of the first paper on the use of MRI in multiple sclerosis in 1981 and the first comprehensive paper on MRI of the brain in 1982. He was also a joint author of many of the first papers describing techniques now commonly used in clinical imaging. These include: inversion recovery and heavily T2-weighted spin echo sequences, Gd based contrast agents, STIR, susceptibility weighted imaging and FLAIR. He has worked at UCSD since 2003 on UTE development which uses radial imaging and high performanc

Covers an in-depth description of UTE MRI, which makes the invisible visible Includes a comprehensive review of contrast mechanisms and developments in quantitative UTE imaging Provides a vast array of special topics and applications in musculoskeletal, neurological, body and vascular diseases