Hormone replacement therapy and endometrium

In recent years hormone replacement therapy (HRT) has become the treatment of choice for women with menopausal symptoms. At the same time, biomedical research continues to generate large amounts of new data on HRT and its impact. Now as never before, gynecologists and general practitioners are in need of easily accessible information on HRT and its physiological effects.
Drawing on the considerable clinical and research experience of its authors, HRT and the Endometrium discusses endometrial changes in the clinical context as well as the molecular level. The book explores techniques for endometrial evaluation in post-menopausal women on HRT, including the first analysis of histomorphometry for quantitating endometrial changes. It emphasizes the connection between postmenopausal bleeding and HRT, summarizing statistical methods for the assessment of bleeding patterns and outlining the clinical options for avoiding this complication. In addition, the authors highlight strategies for overcoming the problem of compliance that are common with HRT.
HRT and the Endometrium is an essential reference for gynecologists, geriatric specialists, and family practitioners. With its comprehensive coverage of clinical guidelines and the underlying molecular events of the menopause, it is an important, timely guide for clinicians concerned with the management of menopausal symptoms.

List of contributors. Foreword. Introduction. Consequences of estrogen deficiency. Menstruation and methods of assessment of uterine bleeding. Analysis of menstrual bleeding diary data. Action of sex steroid hormones. Progestogens and the endometrium. Endometrial history under the effect of sex steroids: the contribution of histomorphometry. Bleeding in post-reproductive years. Evaluation of diagnostic techniques. Management of the menopause. Index.