Haematology and the Asian Patient 51 Clinical Cases

Haematology encompasses a broad range of topics ranging from common and relatively benign conditions such as iron deficiency anaemia, hereditary diseases such as thalassaemia, to haematological malignancies that are often life-threatening. Burgeoning information arising from technological advances in recent years has made these subjects particularly challenging for medical students and non-specialist medical practitioners. This book aims to highlight the pathophysiology, clinical presentations and basic principles in the investigations and managements of haematological diseases that are prevalent in Asia. Each chapter begins with a real-case clinical scenario, followed by a set of questions and is complemented by photomicrographs, data charts and illustrations. Readers will have a grasp of the basic knowledge in haematology and the book will be a useful reference in their academic study and clinical encounters.

About the editors

Haemostasis and Thrombosis

1 Von Willebrand Disease. 2 Severe Haemophilia. 3 Factor VII Deficiency. 4 Acquired haemophilia. 5 Acquired Factor V Inhibitor. 6 Disseminated Intravascular Coagulopathy. 7 Cancer-related Thrombosis.

Myeloid Malignancy

8 Acute Myeloid Leukaemia I. 9 Acute Myeloid Leukaemia II. 10 Myelodysplastic Syndrome. 11 Chronic Myeloid Leukaemia. 12 Essential Thrombocytosis. 13 Polycythemia Vera. 14 Primary Myelofibrosis. 15 Myeloid Neoplasm with Germline Predisposition. 16 Langerhans Cell Histiocytosis.

Lymphoid Malignancy

17 Diffuse Large B-Cell Lymphoma. 18 Waldenström Macroglobulinaemia. 19 Chronic Lymphocytic Leukaemia. 20 Hairy Cell Leukaemia. 21 Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia. 22 Natural Killer Cell Lymphoma. 23 Mycosis Fungoides. 24 T-cell Prolymphocytic Leukaemia. 25 Hodgkin Lymphoma.

Plasma Cell Neoplasms

26 Amyloidosis. 27 Multiple Myeloma. 28 POEMS Syndrome.

Thalassaemia and Haemoglobin Disorders

29 β-Thalassaemia Major. 30 Haemoglobin H Disease. 31 Sickle Cell Disease. 32 Methaemogloblinaemia.

Nutritional and Aplastic Anaemia

33 Aplastic Anaemia. 34 Iron Deficiency Anaemia. 35 Vitamin B12-Deficiency Anaemia.

Haemolytic Anaemia

36 Warm-type Autoimmune Haemolytic Anaemia. 37 Cold Agglutinin Disease. 38 G6PD Deficiency. 39 Hereditary Spherocytosis. 40 Paravalvular Leak. 41 Paroxysmal Nocturnal Haemoglobinuria. 42 Thrombotic Thrombocytopenic Purpura. 43 Atypical Haemolytic Uraemic Syndrome.

Thrombocytopenia

44 Immune Thrombocytopenia. 45 Hereditary Macrothrombocytopenia

Miscellaneous Conditions

46 Castleman Disease. 47 Haemophagocytic Lymphohistiocytosis. 48 Hypereosinophilia. 49 IgG4-related Disease. 50 Lymphadenopathy and Hypergammaglobulinaemia. 51 Paraneoplastic Pemphigus.

Index

Professor Anskar Leung is currently Chair Professor of Haematology and Deputy Chairperson in the Department of Medicine at the University of Hong Kong (HKU). He graduated with MBChB (Hons) and PhD from the Chinese University of Hong Kong (CUHK) in 1996 and joined HKU as Clinical Assistant Professor in 1999. He obtained his specialist qualification in Haematology and Haematological Oncology in 2003 and was promoted to Clinical Associate Professor and Clinical Professor in 2007 and 2012 respectively.

Dr Edmond Ma obtained MBBS and MD degrees from HKU in 1987 and 2004. He is currently the Director of Clinical and Molecular Pathology at the Hong Kong Sanatorium & Hospital, Honorary Clinical Associate Professor at the Department of Pathology HKU, and Clinical Associate Professor (Honorary) at the Department of Anatomical & Cellular Pathology CUHK. He was previously Vice-President and Chief Examiner in Haematology of the Hong Kong College of Pathologists, and past chairman of the Hong Kong Society for the Study of Thalassaemia and Hong Kong Association of Blood Transfusion & Haematology. He is currently Chairman of the Children's Thalassaemia Foundation.