I The Basics
1 Definition & Diagnosis of Sarcopenia in the Research and Clinical Settings
Aldo J. Montano-Loza, Maryam Ebadi
2 The Definition and Diagnosis of Frailty in the Research and Clinical Settings
Hui-Wei Chen, Andres Duarte-Rojo
3 Deciphering the Cirrhotic Patient’s Present Status: The Overlap between Physical Frailty, Disability and Sarcopenia
Elliot B. Tapper
4 The Pathogenesis of Physical Frailty and Sarcopenia
Srinivasan Dasarathy
5 Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation
Stefan Buettner, Jan N.M. IJzermans, Jeroen L.A. van Vugt
6 Nutritional Therapy in the Management of Physical Frailty and Sarcopenia
Manuela Merli, Barbara Lattanzi, Daria D’Ambrosio, Nicoletta Fabrini, Alice Liguori
7 Exercise Training in Patients with Cirrhosis
Graeme M. Purdy, Kenneth J. Riess, Kathleen P. Ismond, Puneeta Tandon
II The Challenges
8 Sex, Age and Ethnicity Dependent Variation in Body Composition: Can There Be a Single Cut-off?
Maria Cristina Gonzalez, Jingjie Xiao, Ilana Roitman Disi
9 Muscle Mass versus Muscle Strength and Performance: Is Muscle Mass Measurement Alone Enough?
Matthew Kappus, Pranab Barman
10 The Role of Changes in Subcutaneous and Visceral Adiposity, Sarcopenic Obesity and Myosteatosis/Muscle Quality in Cirrhosis: How to Diagnose It and Its Contribution to Prognosis
Maryam Ebadi, Aldo J. Montano-Loza
11 Evidence for the Assessment of Physical Frailty and Sarcopenia in Hospitalized Patients and the Role of Assessing Changes Over Time
Guido Stirnimann
12 Frailty and Sarcopenia in the Selection of Candidates for Liver Transplantation
Christopher J. Sonnenday
13 Physical Frailty and Sarcopenia in End Stage Liver Disease: Do They Improve after Liver Transplantation?
Rahima A. Bhanji, Elizabeth J. Carey
14 Measures of Sarcopenia: The Utility of Ultrasound, Bioelectrical Impedance Analysis, and Single-Slice Cross-Sectional Imaging
Marina Mourtzakis, Kirsten Elizabeth Bell
III The Future
15 Upcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and Sarcopenia
Penelope Hey, Marie Sinclair
16 Should Frailty Include Multidimensional and Dynamic Factors?
Darryl B. Rolfson
17 Hepatic Encephalopathy, Sarcopenia and Frailty
Chantal Bémeur, Christopher F. Rose
18 A Research Wish List to Understand, Diagnose and Manage Frailty and Sarcopenia
Michael A. Dunn