Cellular and Biochemical Mechanisms of Obesity, 1st ed. 2021 Advances in Biochemistry in Health and Disease Series, Vol. 23
Langue : Anglais
Coordonnateurs : Tappia Paramjit S., Ramjiawan Bram, Dhalla Naranjan S.
Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.
Two earlier volumes dedicated to the subject of obesity, published in the series ?Advances in Biochemistry in Health and Disease? focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters).
This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.
A. INTRODUCTION
Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla
Asper Clinical Research Institute, St. Boniface Hospital
CR3129-369 Tache Avenue
Winnipeg, Manitoba, Canada R2H 2A6
Email: ptappia@sbrc.ca
Title: Cellular and biochemical mechanisms of obesity
B. Inflammation/cytokines
1. Oreste Gualillo
SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Building C, Travesía da Choupana S/N, Santiago de Compostela 15706, Spain.
Email: oreste.gualillo@sergas.es
Title: The role of inflammation in obesity
2. Kyoungho Suk
Department of Pharmacology, Brain Science & Engineering Institute, Department of Biomedical Science, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea.Email: ksuk@knu.ac.kr
Title: Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity
3. Jennifer M. Monk
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Email: jmonk02@uoguelph.ca
Title: The role of the inflammasome in obesity
4. Geert van Loo
VIB Center for Inflammation Research, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.
Email: geert.vanloo@irc.vib-ugent.beTitle: Adipose tissue macrophages and their polarization in health and obesity
5. Sonia Caprio
Department of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut.
Email: sonia.caprio@yale.edu
Title: Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation
6. Giulia Maurizi
Clinica di Ematologia, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.
Email: g.maurizi@univpm.it
Title: The interplay between adipocytes and immune system cells in the pathophysiology of obesity
C. Hormonal imbalances
1. Agatha A. van der Klaauw
Department of Clinical Biochemistry, Metabolic Research Laboratories - Institute of Metabolic Science, University of Cambridge, Cambridge, England.
Email: av330@medschl.cam.ac.uk
Title: Neuropeptides in Obesity and Metabolic Disease
2. Heather Roff, Colette Jappy
Donor Network West, 12667 Alcosta Boulevard #500, San Ramon, CA 94583; Kaiser Permanente, Redwood City, CA.
Email: Hroff11@gmail.com; colette.jappy@gmail.com
Title: Adiposity and the Role of Neuroendocrine Hormones in Energy Balance
3. Jarosław Kozakowski
Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, 80 Cegłowska St., 01-809 Warsaw, PolandEmail: jkozakowski@cmkp.edu.pl
Title: Obesity in menopause
4. Brigitte Leeners
Division of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstr. 10, CH 8091 Zurich, Switzerland. Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland.
Email: Brigitte.Leeners@usz.ch
Title: Ovarian hormones and obesity
5. Shiying Shao
Division of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China.
Email: shaoshiying@hotmail.com
Title: The role of tissue-specific glucocorticoids in central obesity
6. D. do Nascimento Marreiro
665 Ed. Palazzo Reale, Hugo Napoleão St. apt 2001 Jóquei Teresina, Piauí
Brazil 64048320.
Email: dilina.marreiro@gmail.com
Title: Thyroid function in obesity
7. Terry Hinds
Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine, Toledo, Ohio.
Email: Terry.Hinds@utoledo.edu
Title: Glucocorticoid hormones: cause or cure for obesity
8. Asit Ranjan Ghosh
Centre for Infectious Diseases and Control, School of BioSciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
Email: asitranjanghosh@vit.ac.in
Title: Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota
9. Anna Gavrieli
Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Stoneman 820, Boston, MA 02215.
Email: agavriel@bidmc.harvard.edu
Title: Recent advances in leptin and obesity
10. James R. Sowers
Burns, Diabetes and Cardiovascular Center, University of Missouri, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA.
Email: sowersj@health.missouri.edu
Title: Pathophysiology of obesity due to neurohormonal dysregulation and autophagy
D. Autonomic nervous system
1. Rosa Maria Bruno
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Email: rosamaria.bruno@unipi.it
Title: The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
2. Hideki Katagiri
Division of Advanced Therapeutics for Metabolic Diseases, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Email: katagiri@mail.tains.tohoku.ac.jp
Title: Disturbance of neuronal signals in the pathophysiology of obesity
3. Ana I. Domingos
Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Email: dominan@igc.gulbenkian.pt
Title: The sympathetic neuro-adipose connection and the control of body weight
4. Gino Saravalle
Cardiology Department, S. Luca Hospital, Istituto Auxologico Italiano, Piazza Brescia 20, 20149, Milan, Italy.
Email: g_seravalle@yahoo.com
Title: Sympathetic activation in obesity
5 Zhengtang Qi, Shuzhe Ding
College of Physical Education and Health, East China Normal University, 500 Dongchuan Road, 200241 Shanghai, P.R. China,
Email: qzht79@163.com
Title: Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism
6. Markus P. Schlaich
Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Email: markus.schlaich@uwa.edu.auTitle: Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
7. Elisabeth A. Lambert
Baker IDI Heart & Diabetes Inst., PO Box 6492, St. Kilda Rd. Central, Melbourne, Victoria, 8008, Australia.
Email: elisabeth.lambert@bakeridi.edu.au
Title: Should the sympathetic nervous system be a target to improve obesity?
E. Oxidative stress
1. Alice Carrier
CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix Marseille University , Marseille, France.
Email: alice.carrier@inserm.fr
Title: Metabolic Syndrome and Oxidative Stress: A Complex Relationship
2. Sushil K. Jain
Department of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103,
Email: sjain@lsuhsc.edu
Title: The role of oxidative stress in the pathogenesis of obesity
3. Ashok K. Grover
Department of Medicine, HSC 4N41, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1. Canada.
Email: groverak@mcmaster.ca
Title: How effective are antioxidant supplements in obesity
4. Lucia Marseglia
Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.
Email: lmarseglia@unime.it
Title: Oxidative stress in obesity: a critical component in human diseases
5. Norma L. Gomez-Viquez
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados- Instituto Politécnico Nacional, Mexico City, Mexico.
Email: letyviquez@hotmail.com
Title: Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress
6. Ramaroson Andriantsitohaina
Department of Biochemistry, Université d'Angers, CHU Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.
Email: ramaroson.andriantsitohaina@univ-angers.fr
Title: Oxidative stress and metabolic pathologies: from an adipocentric point of view
7. Dominique Bonnefont-Rousselot
Service de Biochimie Metabolique, Groupe hospitalier Pitie-Salpetriere (Assistance Publique - Hopitaux de Paris), 47-83 boulevard de l'Hopital, 75651 Paris Cedex 13, France.
Email: dominique.rousselot@psl.aphp.fr
Title: Oxidative stress contributes to the pathogenesis of obesity
8. Concepcion M. Aguilera
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, 18100 Armilla, Granada, Spain.
Email: caguiler@ugr.es
Title: The genetics of oxidative stress in obesity
9. Morihiro Matsuda
Institute of Clinical Research, National Hospital Organization, Kure Medical Center, and Chugoku Cancer Center, Hiroshima, Japan.
Email: morihiro-m@kure-nh.go.jp
Title: Increased oxidative stress is associated with adipocyte fat accumulation
10. Atilla Engin
Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey.Email: dr.aengin@gmail.com
Title: The vicious cycle of oxidative stress and obesity
F. Signal Transduction/sensors and regulators of metabolic status
1. Thue W. Schwartz
Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Laboratory for Molecular Pharmacology, Department for Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Email: tws@sund.ku.dk
Title: GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity
2. Laura Herrero
Department of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain.Email: lherrero@ub.edu
Title: Ceramide signaling in obesity
3. Kalyana.Nandipati
Department of Surgery, Creighton University School of Medicine, 601 N. 30th Street, Suite # 3700, Omaha, NE, 68131, USA.
Email: Kalyana.Nandipati@alegent.org
Title: The role of the triggering receptor in the pathophysiology of obesity
4. Pedro Bullon
Department of Oral Medicine and Periodontology, Dental School, University of Seville,
C/Avicena s/n, Seville, 41009, Spain.
Email: pbullon@us.es
Title: The AMPK pathway in the development of obesity
5. Andrew MurphyHaematopoiesis and Leukocyte Biology, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, 3004, Australia.
Email: andrew.murphy@bakeridi.edu.au
Title: Interleukin-1 superfamily: Divergent roles in obesity
6. Y.-X. Tao
Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
Email: taoyaxi@auburn.edu
Title: Ghrelin Receptor Mutations and Human Obesity
Jongsook Kim Kemper
University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Email: jongsook@illinois.edu
Title: Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism
8. Daniel J. Gough
Hudson Institute of Medical Research, 27‐31 Wright Street, Clayton, Victoria 3168, Australia.
Email: daniel.gough@hudson.org.au
Title: JAK/STAT signaling pathway in the development of obesity
9. Long T. Nguyen
Kolling Institute, Level 9, Royal North Shore Hospital, St. Leonard, NSW 2065, Australia.
Email: lngu8923@uni.sydney.edu.au
Title: SIRT1 and SIRT3 as mediators for the development of obesity
10. Tsutomu Sasaki
Laboratory for Metabolic Signaling, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan.
Email: tsutomus@gunma-u.ac.jp
Title: Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
11. Peter Arner
Lipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.
Email: peter.arner@ki.se
Title: Interplay between Obesity and cGMP Signaling in adipose tissue
A compilation of contributions from global experts that present their perspectives on obesity that will stimulate exploration for effective approaches for the prevention of this major public health hazard and concern
Describes recent advancements in the pathogenesis of obesity and related complications that will inspire innovative research for disease prevention worldwide
Universal educational tool for medical students, fellows, residents and graduate students interested in obesity and serve as an attractive resource for health professionals across the world
Date de parution : 12-2022
Ouvrage de 414 p.
15.5x23.5 cm
Date de parution : 12-2021
Ouvrage de 414 p.
15.5x23.5 cm
Thème de Cellular and Biochemical Mechanisms of Obesity :
Mots-clés :
INFLAMMATION; CYTOKINES; HORMONAL IMBALANCES; AUTONOMIC NERVOUS SYSTEM; OXIDATIVE STRESS
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