Caspases: their role in cell death & cell survival (Molecular biology intelligence unit, Vol. 24)

The volume offers insight into the key research topics that involve caspases. Leading experts from various areas of biology and medicine have compiled this volume so that both the novice and the professional will use this as the main reference for caspases for years to come. The reader will learn about the role of caspases in apoptosis signaling, inflammation and cancer therapy while being updated on the methodology used to study caspases and the efforts of pharmaceutical research in targeting caspases.

Preface The Caspase Family, M. Lamkanfi, etal Caspase Cascades in Apoptosis, C. Adrain, et al Caspase Activation at the TNF-R Family Members Death InducingSignaling Complexes (DISCs), M.R. Sprick, H. Walczack Mitochondrial/Apoptosome Dependent Activation of Caspases,K. Cain Modulation of Caspase Activity by CellularInhibitors, K.W. Wagner, et al Virus-Encoded CaspaseInhibitors, G. McFadden, R.W. Moyer ApoptosisDependent and Independent Functions of Caspases, A.Algecirs-Schimnich, et al the Role of Caspases inModulation of Cytokines and Other Molecules in Apoptosis andInflammation, H. Loppnow, et al Caspases, Bcl-2 FamilyProteins and Other Components of the Death Machinery: Their Role inthe Regulation of the Immune Response, M. Pellegrini, A.Strasser Learning from Deficiency: Gene Targeting ofCaspases, T.S. Zheng Caspase Activation in CancerTherapy, S. Fulda, K.-M. Debatin In Situ Activationof Caspases Revealed by Affinity Labeling Their Enzymatic Sites, J.Grabarek, Z. Darzynkiewicz Other Methods of CaspaseActivity Monitoring, H. Hug, et al Caspases asTargets for Drug Development, M. Michalke, et alCaspase-Independent Cell Death Mechanisms, D. Kogel, J.H.M.Prehn. Index.