Biochemical Immunology of Diabetes and Associated Complications

1. Types of Diabetes, mechanism of insulin resistance and associated complications 2. Introduction to Immunology 3. Immune system and diabetes 4. Type-2 diabetes and its effect on immune system 5. Association of oxidative stress with diabetes 6. Biochemical pathways involved in diabetes 7. Immune response and biochemical connection in diabetes 8. immunomodulation and mitigation of diabetic complications 9. Targeting immune system for the treatment of diabetes 10. Inflammatory-mediated responses in development of diabetes 11. Gut-Microbiota-Brain Axis: pathophysiological mechanism in diabetes 12. Association of diabetes mellitus with stress, neuroinflammation other comorbid neuropsychiatric disorders 13. C-reactive protein: a potent inflammatory biomarker in insulin resistance 14. Anti-inflammatory therapy as a promising target for the treatment of diabetes mellitus 15. Role of symbiotic in the treatment of diabetes mellitus via modification of immune system 16. Effect of current antidiabetic drugs on inflammation and immune system 17. Nutraceuticals targeting immune system for the treatment of diabetes 18. Impact of herbal drugs on immune system and diabetes 19. Case studies related to the diseases in question 20. Future Targets

Currently Dr. Pratima is serving as an Assistant Professor in the Department of Biotechnology at National Institute of Pharmaceutical Education and Research (NIPER), Raebareli. Pratima earned her Ph.D. in Biochemistry from University of Lucknow, Lucknow, Uttar Pradesh in 2012. Her doctoral research oriented on ‘Therapeutic Role of L-arginine on free radical scavenging system in ischemic heart diseases.’ During her research, she investigated the vivid role of L-arginine as a significant therapeutic in mitigating the oxidant-antioxidant imbalance that arises during oxidative stress condition and oxygen insult that contributes in the pathogenesis of myocardial infarction induced ischemia and further complications. She contributed her research outputs as publications in high impact journals of repute. The scholar has also been bestowed with ‘Young Scientist Award’ in 2010 from the Society for Immunology and Immunopathology, India.

She had a stint teaching experience in Sri Sathya Sai Institute of Higher Learning (SSSIHL), Anantapur as an Assistant Professor from 2012 to 2017. After gaining a rich experience in Southern India, she relocated to her home town, Lucknow and served as Guest faculty at Integral University, Lucknow till May 2019.

The dynamic phase of her academic career and her zeal towards scientific research granted her a good opportunity as ICMR-Research associateship and Principal Investigator on the project “The role of highly sensitive Troponin-I, highly sensitive C Reactive Protein and NT-proBNP in predicting coronary artery stenosis in patients undergoing Coronary Artery Angiography.”

The ICMR research project was focused on biomarker profiling and analysis of different cardiac and inflammatory biomarkers in coronary artery disease patients to investigate the correlation between the extent of vascular stenosis and level of biomarkers. Research outcome from the work conducted by Pratima as Postdoctoral fellow at Dr. Ram Manohar Loh

• Presents information on Immunosuppression and Immunomodulation that directly or indirectly affects the biochemistry underlying diabetes
• Highlights the association of immunological and biochemical aspects in diabetes to gain a better understanding in handling the disease
• Presents the latest research on inflammatory-mediated responses in the development of diabetes
• Includes a chapter of Case studies related to the diseases in question