Basics of Hematopoietic Stem Cell Transplant, 1st ed. 2023

This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a  question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT

This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

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TABLE OF CONTENTS 

SECTION 1: INTRODUCTION TO BASICS OF T CELLS AND STEM CELL TRANSPLANT 

1.      HISTORY OF STEM CELL TRANSPLANT

2.      BASICS OF STEM CELL TRANSPLANT

3.      STEM CELL MICROENVIRONMENT

4.      HEMATOPOIESIS

5.      T CELL DEVELOPMENT-1

6.      T CELL DEVELOPMENT-2

7.      ROLE OF THYMUS

8.      IMMUNOLOGY OF STEM CELL TRANSPLANT

9.      EARLY T PRECURSOR CELL

10.  REGULATORY T CELLS

11.  TOLERANCE INDUCTION

 SECTION 2: DISEASES OF T CELLS AND STEM CELLS 

13.  INDICATIONS FOR STEM CELL TRANSPLANT

 SECTION 3: PRETRANSPLANT PROCEDURES 

14.  MAJOR HISTOCOMPATIBILITY COMPLEX

15.  APHERESIS

 SECTION 4: RADIO-CHEMOTHERAPEUTIC AGENTS USED IN STEM CELL TRANSPLANT 

17.  CLASSIFICATION OF CONDITIONING REGIMENS

18.  CHEMOTHERAPEUTIC AGENTS

19.  ROLE OF ANTI THYMOCYTE GLOBULIN IN STEM CELL TRANSPLANT

20.  TOTAL BODY IRRADIATION 

SECTION 4: AUTOLOGOUS STEM CELL TRANSPLANT 

21.  INDICATIONS FOR AUTOLOGOUS STEM CELL TRANSPLANT

22.  STEM CELL TRANSPLANT FOR AUTOIMMUNE DISEASES

23.  STEM CELL TRANSPLANT FOR HODGKIN LYMPHOMA

24.  STEM CELL TRANSPLANT FOR NON HODGKIN LYMPHOMA

25.  STEM CELL TRANSPLANT FOR MULTIPLE MYELOMA 

SECTION 5: ALLOGENEIC STEM CELL TRANSPLANT 

26.  STEM CELL TRANSPLANT FOR PRIMARY IMMUNODEFICIENCY DISEASES

27.  STEM CELL TRANSPLANT FOR SEVERE APLASTIC ANEMIA

28.  STEM CELL TRANSPLANT FOR HEMOGLOBINOPATHIES

29.  STEM CELL TRANSPLANT FOR ACUTE LYMPHOBLASTIC LEUKEMIA

30.  STEM CELL TRANSPLANT FOR ACUTE MYELOBLASTIC LEUKEMIA

31.  STEM CELL TRANSPLANT FOR MYELOFIBROSIS 

32.  HAPLOIDENTICAL STEM CELL TRANSPLANT 

SECTION 6: GVHD

33.  ACUTE GVHD

34.  CHRONIC GVHD

SECTION 7: POST TRANSPLANT MONITORING AND MANAGEMENT 

35.  IMMUNE RECONSTITUTION FOLLOWING STEM CELL TRANSPLANT

36.  DRUGS USED POST STEM CELL TRANSPLANT

37.  CHIMERISM

38.  POST TRANSPLANT IMMUNOSUPPRESSION

39.  DONOR LYMPHOCYTE INFUSION

40.  ADOPTIVE T CELL THERAPY 

SECTION 8: INFECTIONS POST STEM CELL TRANSPLANT 

41.  BACTERIAL INFECTIONS

42.  CLOSTRIDIUM DIFFICILE

43.  CYTOMEGALOVIRUS

44.  FUNGAL INFECTIONS

46.  PNEUMOCYSTIS JIROVECII 

SECTION 9: POST TRANSPLANT COMPLICATIONS 

47.  COMPLICATIONS POST STEM CELL TRANSPLANT

48.  ENGRAFTMENT SYNDROME

50.  SINUSOIDAL OBSTRUCTION SYNDROME

51.  RELAPSE FOLLOWING ALLOGENEIC STEM CELL TRANSPLANT

52.  BLOOD GROUP INCOMPATIBILITIES AND AFFECT ON TRANSPLANT

53.  CYTOPENIAS POST STEM CELL TRANSPLANT 

SECTION 10: MISCELLANEOUS 

54.  MISCELLANEOUS

Sanjeev Kumar Sharma has done MBBS and MD (Medicine) from University College of Medical Sciences, Guru Teg Bahadur Hospital, New Delhi. He received gold medal for best thesis in MD (Medicine). During his senior residency from Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, he developed keen interest in hematology. He did his DM (Clinical Hematology) from the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi. He worked as Senior Consultant and Head of the Department in the Department of Hemato-oncology and Bone Marrow Transplantation at BLK-MAX Superspeciality Hospital, New Delhi. Currently he is heading the Department of Hemato-oncology and Bone Marrow Transplantation at Venkateshwar Hospital, Dwarka, New Delhi. He has a vast experience in hematopoietic stem cell transplants spanning over 15 years. He has special interest in the management of hematological malignancies and hematopoietic stem cell transplantation. He has more than 70 publications in peer-reviewed national and international journals and chapters in books. He is also the reviewer for various journals. He is also the author of the best selling hematology multiple choice questions book for medical graduates and hematology residents preparing for various entrance exams titled – MCQs in Hematology. He is a great teacher and has trained DNB students, Fellows and Registrars in clinical hematology and hematopoietic stem cell transplantation. Dr Sharma has also received the Best Citizen of India Award. The current book – Basics of Hematopoietic Stem Cell Transplantation – is intended for young hematologists and transplant Fellows who have started learning stem cell transplantation and face difficulties related to stem cell transplantation. This is a question and answer-based book and covers nearly all aspects of hematopoietic stem cell transplantation.

Demonstrates the topic of Hematopoietic Stem Cell Transplantation in a easy to undersand way

Provides detailed notes in a simple language along with references

Includes special chapters on the common complications of a bone marrow transplant