A Case-Based Guide to Clinical Endocrinology (3^rd Ed., 3rd ed. 2022)

Now in a revised and expanded third edition, this case-based guide emphasizes the latest investigative advances in both imaging and molecular diagnostics and new treatment approaches for a wide variety of common and complex endocrine conditions. Utilizing unique clinical case histories, each main endocrine condition and disorder is curated by a senior Section Editor with an introduction to his or her area covering both physiology and pathophysiology. This introductory chapter is followed by a number of case histories written by invited experts and designed to cover the important relevant pathophysiology, following a consistent chapter format for ease of use, including bulleted objectives, case presentations, review of the diagnosis, lessons learned, and 3-5 multiple-choice review questions. Section headings include the pituitary, thyroid (overactivity, underactivity and cancer) and parathyroid, adrenal disorders, metabolic bone disease, type 2 diabetes, lipid abnormalities, obesity, and pregnancy. Topics new to this edition include PCOS, transgender medicine and the endocrine effects of viral infections.

Part I. Pituitary Disorders.- Introduction to Pituitary Disorders.- Pituitary Tumor Behavior and Disease Severity in Patients with Acromegaly.- Abrupt Weight Gain, Hypertension and Severe Hypokalemia in a Young Male.- Dopamine Agonist-Induced Impulse Control Disorders.- Part II. Thyroid Overactivity.- Introduction to Thyroid Overactivity.- Immunoglobin G4 and Grave’s Orbitopathy.- Subclinical Hyperthyroidism: Case Report and Review of the Literature.- A Case of Gestational Thyrotoxicosis.- Part III. Thyroid Underactivity.- Introduction to Thyroid Underactivity.- Managing Hypothyroidism: Increasing Levothyroxine Requirements.- Gastrointestinal Disease and Levothyroxine Absorption.- Drug-Induced Central Hypothyroidism.- Part IV. Thyroid Cancer.- Introduction to Thyroid Cancer.- Papillary Thyroid Cancer.- Anaplastic Thyroid Carcinoma.- Medullary Thyroid Carcinoma.- Part V. Adrenal Disorders.- Introduction to Adrenal Disorders.- Adrenal Incidentalomas andAutonomous Cortisol Secretion.- Pheochromocytoma.- Ectopic ACTH Syndrome.- Part VI. Primary Hyperparathyroidism.- Introduction to Primary Hyperparathyroidism.- Cinacalcet Use in Primary Hyperparathyroidism.- A Case of Apparently Sporadic Primary Hyperparathyroidism Carrying a Germline Mutation of CDC73 Gene.- Challenges in the Preoperative Localization of Hyperfunctioning Parathyroid Tissue in a Patient with Primary Hyperparathyroidism.- Part VII. Metabolic Bone Diseases.- Introduction to Metabolic Bone Diseases.- Type 2 Diabetes and Bone.- Hypercalcemia and High Bone Mineral Density.- Rare Presentation of Severe Pediatric Rickets.- Part VIII. Endocrine Disorders in Men.- Introduction to Endocrine Disorders in Men.- Adult Onset Hypogonadism.- Congenital Hypogonadotropic Hypogonadism.- Klinefelter Syndrome.- Part IX. Endocrine Disorders in Pregnancy.- Introduction to Endocrine Disorders in Pregnancy.- Prolactinoma in Pregnancy.- Adrenal Insufficiency in Pregnancy.- Pheochromocytoma in Pregnancy.- Diagnosis and Management of Thyroid Cancer in Pregnant Women.- Part X. Type 2 Diabetes Mellitus.- Introduction to Type 2 Diabetes Mellitus.- Initial Diagnosis and Management of Type 2 Diabetes Mellitus.- Outpatient Management of Type 2 Diabetes Mellitus.- Inpatient Management of Type 2 Diabetes Mellitus.- Part XI. Lipid Abnormalities.- Introduction to Lipid Abnormalities.- A Case of Heterozygous Familial Hypercholesterolemia: Success of Long-term Management.- A 53 Year Old Man with Severe Combined Hyperlipidemia and Multiple Medication Sensitivities.- Familial Partial Lipodystrophy Presenting as Extreme Hypertriglyceridemia and Acute Pancreatitis.- Part XII. Obesity.- Introduction to Obesity.- Obesity Assessment and Management Using an Illustrative Case in Severe Mental Illness.- Obesity Management and Use of Very Low Energy Diets.- Obesity Case Management: Bariatric Surgery.- Part XIII. Polycystic Ovary Syndrome.- Introduction to Polycystic Ovary Syndrome.- PCOS and Hirsuties.- PCOS and Reproduction.- PCOS and Insulin Resistance.- PCOS and the Metabolic Syndrome.- Part XIV. Transgender Medicine.- Introduction to Transgender Medicine.- Trans-Masculine Therapy.- Peri-operative Estrogen Considerations for Transgender Women Undergoing Vaginoplasty.- Feminizing Gender-Affirming Hormone Therapy: Special Considerations for Older Adults.- Part XV. Endocrine Effects in Virus Infections.- Introduction to Endocrine Effects in Virus Infections.- Adrenal Function in HIV Infection.- HIV Infection and Lipodystrophy.- Endocrinopathies of SARS-CoV-2.

Utilizes detailed clinical cases of common endocrine disorders, with a focus on the APDEM curriculum Discusses all aspects of endocrine care, with new sections on PCOS, transgender and viral infections An invaluable resource for clinical endocrinologists at all levels of care and experience