Pharmacology of Immunosuppression, 1st ed. 2022 Handbook of Experimental Pharmacology Series, Vol. 272

The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.

Review of the Pathophysiology of the Alloimmune response.- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation.- Anti-proliferative Agents.- Mechanistic Target of Rapamycin (mTOR) Inhibitors.- Corticosteroids.- Induction therapy and antibodies.- Immunosuppression and Heart Transplantation.- Immunosuppression and Lung Transplantation.- Immunosuppression and renal transplant recipients.- Immunosuppression in Rheumatologic and Auto-immune Disease.- Immunosuppression in Bone Marrow Transplantation.- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders.- Novel immunosuppressive agents for the treatment of organ transplants.- Adverse Effects of Immunosuppression: Infections.- Malignancy: An Adverse Effect of Immunosuppression.- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.