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Drug Target Selection and Validation, 1st ed. 2022 Computer-Aided Drug Discovery and Design Series, Vol. 1

Langue : Anglais

Coordonnateurs : Scotti Marcus T., Bellera Carolina L.

Couverture de l’ouvrage Drug Target Selection and Validation
The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis.

Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis.  Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided.  The book concludes with a chapter on chemical and structural databases.

Table of Contents

DRUG DISCOVERY AND DESIGN SERIES Volume 1: Drug Target selection and validation.

 

1.      Drug discovery paradigms: target-based drug discovery

Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, José Alixandre de Sousa Luis, Luciana Scotti, Marcus Tullius Scotti

2.      Drug discovery paradigms: phenotypic-based drug discovery

Alan Talevi, Carolina L. Bellera

3.      Target Identification Approaches in Drug Discovery

Azhar Rasul, Ammara Riaz, Iqra Sarfraz, Samreen Gul Khan, Ghulam Hussain, Rabia Zara, Ayesha Sadiqa, Gul Bushra, Saba Riaz, Muhammad Javid Iqbal, Mudassir Hassan, Khatereh Khorsandi

4.      Introduction to target validation

Cecilia Ortíz, Santiago Ruatta, Marcelo Comini                                       

5.      Structure-based binding pocket detection and druggability assessment Santiago Rodriguez, Juan I. Alice, Carolina L. Bellera, Alan Talevi

6.      Network-Based Target Identification

Zengrui Wu, Yun Tang

7.      The Current State of Precision Medicine and Targeted-Cancer Therapies – Where are We?

Attila Seyhan

8.      Metabolic Control Analysis for drug target selection against human diseases

Javier Belmont-Díaz, Citlali Vázquez, Rusely Encalada, Rafael Moreno-Sánchez, Paul A. M. Michels, Emma Saavedra

9.      Progress on open chemoinformatic tools for drug discovery

José L. Medina-Franco, Rodrigo Gutiérrez-Nieto, Homero Gómez-Velasco

Prof. Marcus Tullius Scotti studied chemical engineering at Universidade de São Paulo (USP - São Paulo University) and finished his degree in 1999. After, he worked for four years in a Brazilian electronics and telecommunications services company called Gradiente. At the same time, he started to study specialization on Industrial Administration at the University of São Paulo. After that, he started post-graduation in organic chemistry at the University of São Paulo in 2003 and finished his Master in 2005 and Ph.D. in 2008. In January of 2009, he moved to João Pessoa and started to work as Professor of Organic Chemistry at Universidade Federal da Paraíba (Federal University of Paraíba), Brazil. At beginning of 2014 finished Post-doc in cheminformatics at Universidade Nova de Lisboa, Portugal,

Prof. Marcus research interests are in the area of chemistry of the natural products, acting on the following subjects: QSAR, Virtual Screening, molecular descriptors, and chemotaxonomy using cheminformatics methods using several statistical tools and machine learning algorithms. He has published over 230 papers.


Prof. Carolina Bellera obtained her Pharmacy degree in 2007 and completed her PhD studies in 2014, both at the National University of La Plata (Argentina). She obtained the award for the best PhD thesis on Bioorganic Chemistry from the Argentinean Chemical Society (2015) and the Award to Innovation from the National University of La Plata (2015). In 2019 she obtained a Tony B Award recognition for outstanding achievement in life sciences and technology in Spain.

She holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2016 (currently as Associate Researcher) and she is the professor in charge of the Medicinal Chemistry course at the Faculty of Exact Sciences, National University of La Plata, since 2018. She has published over 25 papers and 16 book chapters,

Contributors from Brazil, Scotland, Mexico, USA, India, China, Argentina, Uruguay and Pakistan

Addresses both established and new issues in target identification, phenotype, and precision medicine

Presents network pharmacology and gene signature-based drug discovery

Date de parution :

Ouvrage de 257 p.

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Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 147,69 €

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Date de parution :

Ouvrage de 257 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 147,69 €

Ajouter au panier