Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects

Langue : Anglais

Coordonnateurs : Das Sangita, Thomas Sabu, Das Partha Pratim

Couverture de l’ouvrage Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects

Résumé
Sommaire
Biographie
Commentaire

Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects provides a general overview of the development and performance of different novel molecular frameworks as potent vehicles for sensing Chemical Weapons (CWs). The chapters are contributed by leading researchers in the areas of materials science, medical science, chemical science, and nanotechnology from industries, academics, government and private research institutions across the globe. It covers cover topics such as inorganic nanocomposites, hyperbranched polymers, and graphene heterojunctions for effective sensing of CW agents. This book is a highly valuable reference source for graduates, post-graduates, and research scholars primarily in the fields of materials science, medicinal chemistry, organic chemistry, and nanoscience and nanotechnology. In addition, almost all analytical techniques will be discussed, making this a first-rate reference for professors, students, and scientists in many industries.

Introduction

1. Chemical warfare agents: An outlook on past and present technologies 2. Metal-Organic-Framework Composite based rapid Self-Detoxifying Smart Textile Filters for Chemical-Warfare Agents 3. Plasmonic Nanosensors for Chemical Warfare Agents 4. Quantification of DCP (diethylchlorophosphate) for the recognition of organophosphorous chemical warfare agents 5. Advances in gold nanoparticles for optical detection of nerve agents 6. Functionalized two-dimensional photonic crystals for the detection of chemical warfare agents 7. Optically advanced Carbon dots for sensing of harmful toxins 8. Nano Materials in Organophosphate Sensing: Present and Future Perspective 9. Smart hydrogel nanostructured sensor for detection of organophosphorus chemical warfare nerve agents 10. Graphene based nanocomposites for detection of chemical messengers in nervous system 11. Aptamer based approaches for sensing harmful synthetic and natural toxins 12. MOFs derived nanoarchitectures for the detection of phenolic compounds 13. Sensing of Phenol and Chlorophenols using Carbon Nanotubes Modified Glassy Carbon Electrode 14. Nanotubes tethered laccase biosensor for sensing of chlorophenol substances 15. Use of organic compounds as Medical Products for the therapeutic treatment exposed to CW's agents 16. An assessment of Chemical Warfare Agents in soils: Detection, Distribution and Ecotoxicology 17. Assessment of the impact of chemical weapons disposal in the ocean according to international conventions 18. Chemical Warfare: Unprecedented Environmental Threat 19. Clinical Symptoms of Chemical Warfare Agents Toxicity including Mustards, Halogenated Oximes, Arsenicals, Toxins Poisoning 20. Advances targeted therapy in toxicology and medical treatment of chemical warfare nerve agents 21. The reversible inhibitors of acetylcholinestrerase as pre-treatment options against nerve agents intoxications 22. Paraoxonase 1 as a potential prophylactic countermeasure against nerve agent poisoning 23. Potential Alternative treatments and Routes of Administrations: Chemical Warfare Agents Poisoning 24. Therapeutic Treatment of Nerve Agent toxicity 25. Carbon-nanomaterial modified molecularly imprinted polymers for the sensing of Organophosphorus simulants 26. Carbon-nanomaterial modified recognition platforms for the sensing of organophosphorous simulants 27. Graphene-based nanocomposites for electrochemical sensing of Organophosphate triesters 28. Synthesis of simulants of nerve agents for the assays of AChE inhibition 29. Toxicological and Pharmacological Aspects of Organophosphorus Nerve Agents

Dr. Sangita Das is working as Newton International Fellow at Durham University, England, United Kingdom. She also works as a visiting professor in the Department of Energy Science in Mahatma Gandhi University, Kerala, India. She received her B. Sc. degree with honors in chemistry in 2008 from the University of Calcutta, Kolkata, West Bengal, India. She obtained her M. Sc. degree in chemistry with organic specialization in 2010 from the same university. She had qualified the all India (CSIR–JRF) NET, and then she joined “The Goswami Group, Department of Chemistry, IIEST for her doctoral work under the supervision of Prof. Shyamaprosad Goswami. She got Ph.D. in 2016. Her areas of research interest include molecular recognition; design of fluorescence chemosensors; and characterization of fluorescence probe (detection of metal ions, anions, reactive oxygen species, nerve gas, and other environmentally hazardous species, etc.); aggregation-induced emission dyes and solid-state emitters, and synthesis of compounds with antidiabetic activity. She is now working as a Newton International Fellow in the United Kingdom. Her current research activities include the development of compounds as HDAC inhibitors, experimental and theoretical investigations of electronic structure of transition metal complexes with redox noninnocent ligands, and computational chemistry (DFT, TDDFT calculations).

Professor Sabu Thomas is the Director of Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India. He is also currently the Chairman of the Trivandrum Engineering Science and Technology Research Park (TrESPARK), Trivandrum, Kerala, India. He was the former Vice Chancellor of Mahatma Gandhi University, Kottayam, Kerala, India. Prof. Thomas is a highly committed teacher and a remarkably active researcher well-known nationally and internationally for his outstanding contributions in polymer science and nanotechnology. He has published over 140

Provides an efficient, reliable, and highly versatile approach for the synthesis of different molecular systems suitable for diversity-oriented strategies, structure-activity studies and molecular tailoring for the sensing of chemical warfare agents
Goes into depth on new binary organogels, discrete carbon nanomaterials (CNMs) and molecularly imprinted polymers (MIPs) and has endowed electrochemical chemosensors (ECCSs) with high selectivity and sensitivity towards the detection of chemical warfare agent
Highlights in detail the detection of CWs by composite optical waveguide sensors, and describes disposable biofilm biosensors for sensitive detection of biotoxicity in water with treatment of nerve agent poisoning