Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index.

This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations.

Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.

1. Introduction to cancer cell biology2. Current practice in cancer pharmacotherapy3. Current practices in oncology drug delivery4. Emerging need of advanced drug delivery systems in cancer5. Target drug delivery in cancer6. Material and strategies used in oncology drug delivery7. Hydrogel based drug delivery systems for cancer therapy8. Recent advances in drug formulation development for targeting lung cancer9. Advanced drug delivery systems in lung cancer10. Advanced drug delivery systems in breast cancer11. Advance drug delivery systems in the treatment of ovarian cancer12. Advanced drug delivery systems in blood cancer13. Advanced drug delivery systems in kidney cancer14. Advance drug delivery systems in glioblastoma15. Advanced drug delivery systems in prostate cancer16. Nanomedicine-based doxorubicin delivery for skin cancer with theranostic potential17. Advanced drug delivery systems in liver cancer18. Advanced drug delivery systems in hepatocellular carcinoma19. Advanced drug delivery systems in oral cancer20. Advance drug delivery system in pancreatic cancer21. Advanced drug delivery system in colorectal cancer22. Current strategies in targeted anticancer drug delivery systems to brain23. Neuroblastoma: Current advancements and future therapeutics24. Nanoparticulate systems and their translation potential for breast cancer therapeutics25. Advancement on nanoparticle-based drug delivery systems for cancer therapy26. Advances in polymeric nanoparticles for drug delivery systems in cancer: Production and characterization27. Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics28. Advancements on microparticles-based drug delivery systems for cancer therapy29. Microparticles for cancer therapy30. Biosynthetic exosome nanoparticles isolation, characterization, and their diagnostic and therapeutic applications31. Advances in delivery of nanomedicines and theranostics for targeting breast cancer32. Bioresponsive nano-theranostics approaches for cancer targeting33. Two-dimensional materials-based nanoplatforms for lung cancer management: Synthesis, properties, and targeted therapy34. Cell and gene therapies - Emerging technologies and drug delivery systems for treating brain cancer35. Targeting siRNAs in cancer drug delivery36. Targeting micro-ribonucleic acid (miRNA) in cancer using advanced drug delivery systems37. Organic nanocarriers for targeted delivery of anticancer agents38. Targeting cancer using phytoconstituents-based drug delivery39. Clinical trials in drug delivery for the treatment of cancer40. Future prospects and challenges in cancer drug delivery

Dr. Kamal Dua is a Senior Lecturer in the Discipline of Pharmacy at the Graduate School of Health, University of Technology Sydney (UTS), Australia. He has research experience of over many years in the field of drug delivery systems targeting inflammatory diseases. Dr. Dua researches in two complementary areas; drug delivery and immunology, specifically addressing how these disciplines can advance one another, helping the community to live longer and healthier. This is evidenced by his extensive publication record in reputed journals. Dr. Dua’s research interests focus on harnessing the pharmaceutical potential of modulating critical regulators such as Interleukins and microRNAs and developing new and effective drug delivery formulations for the management of chronic airway diseases. He has published more than 80 research articles in peer-reviewed international journals and authored or co-authored four books. He is an active member of many national and international professional societies.

• Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer
• Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers
• Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems