Cellular proteins and their ligand fatty acids : emerging role in gene expression, health and disease

Long chain fatty acids bound to specific proteins are important to the cell as a source of metabolic energy, and as substrates for membrane biogenesis and signaling molecules. According to the latest findings, they are involved in the regulation of many cellular processes. This book describes fatty acid binding proteins and their derivatives, covering aspects such as structure and function, ligand specificity, delivery of ligands, their role and expression in nutrition, health, and disease, dealing with membrane fatty acid transporters in depth. In view of the increasing importance of these binding proteins in cellular growth, development, and such disease processes as obesity, insulin resistance, cardiac disease, cancer, and inflammation, internationally renowned editors and authors have teamed up to compile this first handbook on the topic. It reflects the current state within the field and will be indispensable for basic scientists, health and nutrition professionals in industry and clinics as well as postgraduate students.

THE MOLECULAR BASIS OF PROTEIN-LIPID INTERACTION AND FUNCTIONAL CONSEQUENCES. Transport/binding proteins of cellular membranes. Binding proteins of aqueous cell compartments. Nuclear transcription factors that bind fatty acids. ROLE OF THE PROTEINS IN CELLULAR HOMEOSTASIS. Cellular growth/differentiation . Cell signaling and metabolism. Role of binding proteins in disease.