Transplant Oncology A Frontier in Multidisciplinary Cancer Care

Transplant Oncology: A Frontier in Multidisciplinary Cancer Care summarizes new and evolving scientific findings and discoveries in the field of cancer and transplants and gives guidance on future directions and related research. With a strong focus on transplant oncology, the book examines new and evolving topics, including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field such as using circulating tumor DNA (ctDNA) as a tool for minimal disease detection, surveillance, and treatment response evaluation as well as rejection assessment and detection in transplant patient for oncological indications. Sections cover applications of transplant medicine and surgery in oncology to improve patient survival outcome and quality of life. The book gives insight into anticancer strategies, such as initiating studies in genomics and cancer immunogenomics based on new insights in liver cancer. In addition, it describes how the adoption of surgical transplantation techniques in oncology has improved conventional resection and bridged the gap between tumor and transplant immunology. This is a must have reference for all those that want to be familiar and up-to-date with the dynamic changes in the field including practicing physicians, scientists, and trainees.

I. Transplant Oncology, concept, history, and evolving field II. Transplantations for oncological indications 1. Hepatocellular Carcinoma 2. Cholangiocarcinoma 3. Colorectal cancer 4. Neuroendocrine tumors 5. Hepatoblastoma III. Transplant Oncology and Immunotherapy 1. Immunotherapy and solid organ transplantsa. Immunotherapy and liver transplants i. Immune-based therapy approach in HCC management ii. Immunotherapy peri-liver transplantation b. Immunotherapy and solid organ transplant 2. Immunotherapy and Hematopoietic Stem Cell Transplants 3. Immunotherapy In the era of Transplant Oncology: risks and complications 4. Immunotherapy and immunosuppressants: Considerations in the clinical practice IV. Transplant Oncology and precision medicine 1. Molecular profiling and Next-Generation Sequencing (NGS) applications in transplant oncology 2. Circulating tumor DNA (ctDNA) new and evolving tool in solid organ transplantation 3. Cell-free DNA (cfDNA) biomarkers for solid organ transplant rejection 4. Artificial intelligence in transplant Oncology V. Solid organ transplant and cancers considerations 1. Secondary cancers post solid organ transplant: risk, prevention, and management 2. History of cancer and transplant clearance: Considerations prior to transplantations VI. Surgical aspects of transplant oncology 1. Updates on liver transplantations and robotic applications for liver cancers indications 2. Updates on liver transplantations for Cholangiocarcinoma indications 3. Liver transplantations for secondary cancers indications 4. New strategies for two-stage hepatectomy 5. Partial liver transplantation 6. Challenges of liver transplantations for transplant oncology indications 7. Future directions for liver transplantations in the transplant oncology field

• Illustrates the concept and history of transplant oncology as an evolving field for the management of hepatocellular carcinoma
• Discusses the utility and safety of immunotherapy in the transplant setting
• Summarizes the utilization of immune checkpoint inhibitor therapies in pre-and post-liver transplants for HCC patients and discusses the assessment of immune checkpoint inhibitor regulators that might determine liver transplant outcomes
• Highlights new and evolving topics including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field, including treatment and rejection assessment