The Physics of Protein Structure and Dynamics When and Why Proteins Fold or Don’t Fold
Langue : Anglais
Auteur : Schweitzer-Stenner Reinhard
The Physics of Protein Structure and Dynamics: When and Why Proteins Fold or Don’t Fold addresses an overlooked issue in current books in the field - folding, misfolding, and intrinsically disordered proteins (vide infra). The book looks at protein folding and intrinsically disordered proteins, which must be seen as heavily interrelated topics that need to be viewed together. The book also looks at the physics of protein/peptide aggregation. Since intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow), IDPs and protein self-assembly must be considered together.
Moreover, protein aggregation cannot be separated from protein folding since it is frequently the product of misfolding. The proposed book will demonstrate the relationships between protein folding, non-folding and aggregation and emphasize the underlying physics.
Moreover, protein aggregation cannot be separated from protein folding since it is frequently the product of misfolding. The proposed book will demonstrate the relationships between protein folding, non-folding and aggregation and emphasize the underlying physics.
1. Introduction 2. Intramolecular and Intermolecular Interactions 3. Protein Dynamics 4. Protein Folding and Unfolding 5. Intrinsically disordered proteins and poly-peptides 6. Misfolding and peptide/protein aggregation 7. Summary and Outlook
Research Background: Over the last forty years the author has conducted research in various areas of modern biophysical chemistry: (1) Structure and function of heme proteins studied mostly with resonance Raman spectroscopy, (2) Folding and unfolding of cytochrome c in solution and anionic surfaces, (3) Ligand-receptor binding as a trigger of mast cell and basophil activation, (4) Vibrational dynamics of peptides, (5) Conformational analysis of peptides used as model systems for unfolded and disordered proteins, (6) Aggregation, self-assembly and gelation of short and ultrashort peptides
Publication record: 211 peer reviewed papers and book articles; he is the editor of the book: Protein and Peptide Folding, Misfolding and Non-Folding, Wiley and Sons, ISBN 978-0-470-59169-7
Teaching experience: Over the last 40 years has taught classes in biophysics, biophysical chemistry, atomic and molecular physics, spectroscopy, statistical thermodynamics and bioinorganic chemistry on the undergraduate and graduate level
Publication record: 211 peer reviewed papers and book articles; he is the editor of the book: Protein and Peptide Folding, Misfolding and Non-Folding, Wiley and Sons, ISBN 978-0-470-59169-7
Teaching experience: Over the last 40 years has taught classes in biophysics, biophysical chemistry, atomic and molecular physics, spectroscopy, statistical thermodynamics and bioinorganic chemistry on the undergraduate and graduate level
- Provides an in-depth overview of the physical concepts that govern different aspects of protein folding, disorder, and self-assembly
- Offers a unique source for teaching current protein physics issues
- Facilitates a learning process suitable for research-oriented students
Date de parution : 09-2024
Ouvrage de 275 p.
15x22.8 cm
Thèmes de The Physics of Protein Structure and Dynamics :
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