Tendon Regeneration (2^nd Ed.) Understanding Tissue Physiology and Development to Engineer Functional Substitutes

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field?s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine.

Section I Biology and Physiology of Tendons
1. Regenerating Tendons: Lessons from Development
2. Mechanobiology of Embryonic and Adult Tendons and Tendon Interfaces
3. Tendon Physiology and Mechanical Behavior Structure-Function Relationships
4. Tendon Resident Cells - Functions and Features
5. Molecular and Biological Mechanisms of Tendon Homeostasis and Repair

Section II Pathologies and Repair of Tendons
6. Tendinopathy Triad - Mechnosenising, ECM, and Inflammation
7. Medical Considerations in Tendinopathy
8. Etiology, Pathology, and Healing of Tendon Injury and Disease
9. Mechanics and Mechanisms of Tendon Disease and Regeneration
10. Tendon Aging and Degeneration
11. The Veterinarian Perspective: Comparative Anatomy, Animal Models and Bioengineering of Tendons

Section III Tendon Tissue Engineering and Regenerative Medicine Approaches
12. Cell-Based Approaches for Tendon Regeneration
13. Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration
14. Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues
15. Multifactorial Tendon Tissue Engineering Strategies
16. Tendon Interface Engineering Approaches

Section IV Translating Tendon Regenerative Medicine Strategies
17. Transitional Tendinopathy: Are We There Yet?
18. Translational Challenges at the Interfaces

Manuela E. Gomes is Associate Professor and Vice-President of the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Dr. Gomes is also on the Board of Directors of the Portuguese Associate Laboratory that gathers the Institute for Life and Health Sciences of the University of Minho and the 3B´s Research Group and was responsible for the implementation of the Quality Management System at the 3B’s. She is a board member of the Doctoral Program on Tissue Engineering Regenerative Medicine and Stem Cells and has been part of numerous European and national/regional projects as PI/member. She was awarded a Consolidator Grant and a PoC from the European Research Council that started in 2018 and 2022, respectively. She has edited 2 books, 1 encyclopedia, and is author of 43 book chapters, 226 scientific papers in journals with international peer-review, 9 patents and over 344 communications in international conferences.
Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.
Márcia T. R