Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration

Langue : Anglais

Coordonnateur : Bhattacharya Sanjoy K.

Couverture de l’ouvrage Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration

Résumé
Sommaire
Biographie
Commentaire

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome. The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries.

1. Historic accounts of neuron regeneration
2. Reagents for neuron regeneration structural studies
3. Assessments for functional regeneration
4. In vitro methods
5. In vivo models and pharmacological reagents
6. Systems biology approaches
7. Application of machine learning and artificial intelligence
8. Standardization approaches
9. Re-connectivity and new approaches
10. Regeneration applicable to other fields
11. Food and drug administration outlook for new treatments in this area
12. Approval processes and clinically relevant aspects
13. Enterprise formation strategies
14. Protocols and miscellaneous topics

Sanjoy K. Bhattacharya, Ph.D. is a Tenured Professor of Ophthalmology and Research Scientist at the University of Miami Bascom Palmer Eye Institute. He is the founding Director of the Miami Integrative Metabolomics Research Center, the Director of the Ophthalmology Mass Spectrometry Core Facility/Shared Instrument Facility, and the Director of the Graduate Program in Vision Science and Investigative Ophthalmology at Miller School of Medicine. His research adopts a multidisciplinary approach which includes mass spectrometric proteomic and lipidomic approaches to study neurodegenerative diseases, and majorly focus is a group of progressive irreversible blinding diseases collectively called glaucoma and also a group of demyelinating diseases termed multiple sclerosis that frequently is associated with visual impairment preceding neurological deficits.

Includes updates on the use of multi-omics datasets for selecting molecules for axon regeneration
Bridges the preclinical and clinical world, from selection of the molecules to outcome leading to IND filing and their use
Includes system level knowledge needed for central nervous system axon and dendrite regeneration, and standardizes the system level biology for axon regeneration
Explores the current state of multi-omics in axon and dendrite regeneration in the optic nerve and its comparison to other CNS regeneration