Proteolytic Enzymes and their Inhibitors in Infectious Pathogens Foundations and Frontiers in Enzymology Series
Langue : Anglais
Coordonnateur : Coetzer Theresa
Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.
Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.
Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.
1. Overview of pathogen proteases and their endogenous macromolecular inhibitors
2. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors
3. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling
4. Aspartic proteases and their inhibitors in Trypanosomatids
5. Subtype-specific HIV-1 protease and the role of hinge and flap dynamics in drug resistance: a subtype C narrative
6. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms
7. Cathepsin-like proteases of protozoa
8. Metallo-aminopeptidases in parasites and bacteria
9. Bacterial signal peptidases
10. Ecotins of bacteria and protozoa
11. Oligopeptidase B popping up in many pathogens as a virulence factor
12. Bacterial/Mycobacterial proteasome
2. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors
3. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling
4. Aspartic proteases and their inhibitors in Trypanosomatids
5. Subtype-specific HIV-1 protease and the role of hinge and flap dynamics in drug resistance: a subtype C narrative
6. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms
7. Cathepsin-like proteases of protozoa
8. Metallo-aminopeptidases in parasites and bacteria
9. Bacterial signal peptidases
10. Ecotins of bacteria and protozoa
11. Oligopeptidase B popping up in many pathogens as a virulence factor
12. Bacterial/Mycobacterial proteasome
Professor Theresa Coetzer’s research focusses on proteolytic enzymes as diagnostic and drug targets in African parasitic diseases: mainly animal and human trypanosomiasis (nagana and sleeping sickness) and also trichinellosis and theileriosis. She also has expertise in producing antibodies in chickens against the whole proteases and against peptides corresponding to epitopes identified in silico. Dr. Coetzer holds a DST-NRF South African Research Chair Initiative (SARChI), as Chair in Proteolysis in Haemostasis, Health and Disease.
- Discusses proteolytic enzymes of parasites, bacteria, and viruses arranged by peptide bond cleavage classes, for improved integration of information across the infectious organisms
- Includes information on the structure and interaction with proteases of macromolecular protease inhibitors, and how these structures can be engineered to provide more potent and specific protease inhibitors
- Provides instructions in methods and technologies to identify physiological protease substrates, their cleavage specificities, and inhibitors
- Features rich illustrations and diagrams of core concepts, including informative three-dimensional protein structures and molecular interactions
Date de parution : 11-2024
Ouvrage de 472 p.
19x23.3 cm
Thème de Proteolytic Enzymes and their Inhibitors in Infectious... :
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