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Proteins A Structural Biology Perspective

Langue : Anglais

Auteur :

Couverture de l’ouvrage Proteins

Proteins: A Structural Biology Perspective covers basic concepts of protein science that is illustrated by practical examples. The book will help biologists bear in mind that to investigate the molecular mechanism of the biological system they have been working on, one should always seek the answer from structural perspective. The book also helps structural biologists and students in the structure field to be aware that a protein structure is a beautiful result of the long molecular evolution. The book focuses on two points: from genomic perspective and from protein-protein interaction view of protein structures.

1. Protein-in-module and gene-in-piece. How proteins evolve 2. Sequence identity of a domain 3. Protein three-dimensional structure information is in sequence: A. AlphaFold structure prediction 4.“Protein three-dimensional structure information is in sequence: B. Cellular immunity 5. Intrinsically disordered proteins are not really disordered 6. Protein structure make sense in every corner 7. Protein-protein interaction drives life: specificity and affinity 8. Virus infection at protein level 9. How cells adhere 10. The neuronal wiring 11. Lock-and-unlock 12. Some unique structural and functional features of individual amino acids in proteins

Jia-huai Wang is Associate professor at the Dana-Farber Cancer Institute, Harvard Medical School, USA. As a veteran structural biologist specialized in cell surface receptors functioning in immune system and nervous system he has around 140 peer-reviewed papers published, including 11 articles in Nature, Science and Cell. When in China, in the early 1970’s, he was the team member which determined the structure of insulin, one of the world’s first dozen protein structures solved. Since 1988 he has been working at Harvard. As a leading author, he has published a series of extremely important structures, such as the first virus structure CD4, the first cell adhesion interacting complex CD2/CD58, the ground-breaking preTCR-ligand interacting complex and the prototypical axon guidance cue netrin-1 interactions. He has a deep understanding about protein structure and how a protein functions.
  • Features some basic concepts of protein science as illustrated by practical examples
  • Helps biologists bear in mind that to investigate the molecular mechanism of the biological system they have been working on, one should always seek the answer from structural perspective
  • Aids structural biologists and students in the structure field to be aware of the structure of proteins
  • Focuses on two points: From a genomic perspective and from a protein-protein interaction view of protein structures

Date de parution :

Ouvrage de 210 p.

15x22.8 cm

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158,56 €

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Thèmes de Proteins :