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Handbook of Proteolytic Enzymes (4th Ed.) Cysteine Peptidases

Langue : Anglais

Coordonnateur : Rawlings Neil D.

The Handbook of Proteolytic Enzymes: Cysteine Peptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition?is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes. This volume,?Cysteine Peptidases, includes over 300 chapters on known cysteine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Volume 1: Metallopeptidases
Volume 2: Serine and threonine peptidases
Volume 3: Cysteine peptidases
Volume 4: Aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms
Volume 5: Naturally-occurring and synthetic inhibitors of proteolytic enzymes.

CYSTEINE PEPTIDASES (Volume 3) New chapters Pseudotzain Falcipain-2 Falcipain-3 Rhodesain OTULIN peptidase Ubiquitinyl hydrolase-BAP1 Butelase 1 CED-3 peptidase Caspase-11 Metacaspase-9 Middle East respiratory syndrome coronavirus papain-like peptidase Ubiquitin-specific peptidase 9X Ubiquitin-specific peptidase 11 Ubiquitin-specific peptidase 12 Ubiquitin-specific peptidase 18 Ubiquitin-specific peptidase 19 Ubiquitin-specific peptidase 20 Ubiquitin-specific peptidase 21 Ubiquitin-specific peptidase 26 Ubiquitin-specific peptidase 28 Ubiquitin-specific peptidase 30 Ubiquitin-specific endopeptidase 39 MERS coronavirus picornain 3C-like peptidase D-alanyl-glycyl peptidase Autophagin-1 DJ-1 putative peptidase Major revisions Papain Stem bromelain Actinidin Cathepsin B Cathepsin K Cathepsin L Cathepsin S Cathepsin X Falcipain-2 Falcipain-3 Dipeptidyl-peptidase I Peptidase 1 (mite) Cruzipain Calpain-1 Calpain-2 Calpain-3 Streptopain Ubiquitinyl hydrolase-L1 Severe acute respiratory syndrome coronavirus papain-like peptidase Ubiquitin-specific peptidase 4 Ubiquitin-specific peptidase 7 Ubiquitin-specific peptidase 15 Legumain (plant beta form) Legumain, animal-type Caspase-1 Caspase-3 Caspase-7 Caspase-8 Caspase-9 Gingipain K Separase (Homo sapiens-type) Sindbis virus-type nsP2 peptidase Enterovirus picornain 2A Tobacco etch virus NIa peptidase SARS coronavirus picornain 3C-like peptidase Calicivirin
Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
  • The only comprehensive book on cysteine peptidases, with over 300 peptides included
  • Each chapter written by experts in their field, on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research
  • Fully searchable text, 2D and 3D structures of peptidases in color, and links directly to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research, and discusses recent drug trials