Biomarkers in Kidney Transplantation Clinical Aspects and Laboratory Determination Clinical Aspects and Laboratory Determination Series

Langue : Anglais

Auteurs : Pattanaik Dr Smita, Sharma Dr Ashish

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Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

1. Organ transplantation: Past, Present and Future
2. Trends in organ transplantation
3. Immunobiology in organ transplantation
4. Immunosuppression in solid organ transplantation
5. Challenges in therapeutic drug monitoring of immunosuppressants
6. Biomarkers in transplantation: An overview
7. Biomarkers for risk of rejection
8. Biomarkers predicting the response to immunosuppressant therapy
9. Biomarkers predicting risk of recurrence of the primary renal disease
10. Biomarkers for detecting opportunistic infections
11. Biomarkers detecting organ toxicity with immunosupressant drugs
12. Biomarkers for drug development in organ transplantation
13. Commercially available biomarkers for renal transplantation
14. The current challenges, unmet need and future directions

Smita Pattanaik received her MBBS from Utkal University, an MD in Pharmacology from PGIMER Chandigarh, DNB in Pharmacology from National Board of Examination New Delhi and DM in Clinical Pharmacology from PGIMER Chandigarh. Her current research focuses on concentrate on clinical pharmacology of immunosuppressant drugs, therapeutic drug monitoring and dose individualization (PK/PD) modeling and pharmacogenomics, clinical research methodology and biostatistics, clinical pharmacology of genitourinary system and bladder cancer chemotherapy.
Ashish Sharma is a Professor and Head of the Institution Department of Research and Transplantation Surgey, Postgraduate Institute of Medical Education and Research. He has contributed more than 50 publications in national and international journals. He started laparoscopic donor nephrectomy at the Institute and has trained transplant surgeons from different part of India in this technique. His active involvement in promoting deceases donors and improving protocols for identification and counselling of brainstem dead donors has led to increased deceased organ donations. He also initiated simultaneous kidney pancreas transplantation.

Includes comprehensive coverage on all available biomarkers to predict organ rejection
Provides guidance on how to interpret test results of all available biomarkers
Covers possible sources of errors in measuring biomarkers to eliminate issues of interference