Protein Misfolding in Neurodegenerative Diseases

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson?s disease, ALS, Creutzfeldt-Jakob disease, and more.

1. Maintenance of balanced proteome homeostasis 2. Determinants of protein misfolding, aggregation in neuronal cell death 3. Classification, structure, and function of protein aggregates in proteinopathies 4. Protein aggregation and cellular and molecular mechanisms in neurodegenerative disease 5. Advances in methods to detect and study protein aggregation 6. Organelle specific protein quality control 7. Molecular chaperones and co-chaperones in proteostasis 8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal proteolytic pathways 9. Alterations in protein quality control 10. Alternate mechanisms to maintain proteome homeostasis 11. Advances in developing novel therapeutics, strategies, approaches and use of emerging techniques 12. Challenges in translating laboratory findings to drug development 13. Advancements in drug delivery technologies for protein misfolding diseases

• Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders
• Describes methods for detection and analysis of protein aggregates
• Features advancements in therapeutics and emerging techniques to treat these disorders
• Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson’s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington’s and other related proteinopathies