Prostate Cancer, 1st ed. 2024 Advancements in the Pathogenesis, Diagnosis and Personalized Therapy

This book provides an in-depth exploration of the biology of prostate cancer, from its cellular origins to its clinical manifestations and therapeutic options. In addition to thoroughly covering a variety of diagnostic methods, radical procedures, radiation therapy, hormone therapy, and surgical techniques for prostatectomy, the book seeks to improve the understanding of the development of prostate cancer.

Delving into the latest research and scientific advancements, the book starts by shedding light on the critical role of genetic susceptibility, redox signaling, apoptosis, epigenomics, transcriptomics, and metabolic reprogramming in prostate cancer development and progression. In the following section key concepts in prostate cancer diagnostics are covered. This includes the diagnostic, prognostic, and theranostic potential of miRNAs in prostate cancer; the necessity of biopsy; and the importance of histopathological and molecular markers in assessing aggressivity. It also explores recent advances in tumor markers for early detection and monitoring, as well as biological markers of therapeutic response. The book concludes by offering a wealth of knowledge on current treatment options for prostate cancer, including surgical treatments, hormone therapy for advanced cases, the use of apheresis in personalized cell-mediated treatment, pharmacogenomics and precision therapy challenges and perspectives, stereotactic radiotherapy, and treatment for castration-resistant prostate cancer.

Scientists and medical professionals interested in basic and clinical research in urology and oncology will find this book to be a useful reference. It is a helpful tool for preparing medical specialization in pathology, oncology, urology, clinical biochemistry, laboratory medicine, diagnostic radiology, oncologic radiology, and related fields of cancer research. With its integrative approach to diagnostics and focus on recent scientific breakthroughs, this book empowers readers to deepen their understanding of prostate cancer and enhance their ability to advance basic and clinical research to treat this pervasive disease.

Professor Gordana Kocic, MD, PhD is a Full Professor of Biochemistry at Medical Faculty University of Nis (Serbia). She is a specialist in medical biochemistry and a subspecialist in three areas of clinical biochemistry: immunoassays, biochemical oncology, and biochemical endocrinology. She is a full member of the Medical Department of the Medical Academy of the Serbian Medical Association, a member of the Scientific Council University of Nis, the Secretary of the Branch of the Academy of the Serbian Medical Association in Niš (Serbia). Professor Gordana Kocic's research has been published in 162 scientific papers in journals from the Journal Citation Report - SCI list, a significant amount of which are in the Q1 category; she is one of authors of textbooks: Biochemistry (Medical Faculty, University of Niš), Clinical Biochemistry (Medical Faculty University of Nis), and Selected Chapters in Urology (Institute for textbooks Belgrade); monographs: "Biochemistry of Free Radicals" and "Oxidative Modification of Biomolecules"; six chapters in monographs of national impact. She presented her scientific achievements published as supplements to prestigious journals. Four registrable patents provide as documentation of innovation activities. The prizes she received are: for PhD thesis, the best scientific articles awarded by the Serbian Medical Society branch Nis, the award for scientific achievement, "Best technological innovation for 2010", by Chamber of Commerce Republic Serbia's.  As a Principal Investigator of the projects of the Ministry of Education and Science Republic of Serbia and Fund of Science Republic of Serbia (No 7750154 (NPATPETTMPCB) and in the NETCHEM project, she has been overseeing and organizing a number of project research activities. She collaborated on two international bilateral projects with Slovenia and TEMPUS projects, Erasmus Plus project

Discusses basics in prostate cancer etiology, genetic susceptibility, epigenetics, and more

Highlights modern diagnostic techniques, tumor markers, surgical, radio and hormonal therapy options

Provides the most recent information on prostate cancer to researchers and medical practitioners