Postinjury Multiple Organ Failure , 1st ed. 2022 Hot Topics in Acute Care Surgery and Trauma Series

This book on post-injury multiple organ failure (MOF) offers a comprehensive overview and clinically focused practical guide to treating the condition. MOF is arguably the most difficult complication to manage in polytrauma patients and is responsible for the majority of trauma deaths among patients who survived the first 24 hours after injury. Beyond mortality, it has a major impact on healthcare resource utilization and a persistent negative effect on patients? long-term reported outcomes.

This book is edited by surgeons who are passionate about the topic, and about optimizing the outcomes for polytrauma patients. Grasping the fascinating pathophysiology of MOF is essential for providing patients with quality early care. Each chapter highlights key learning objectives, historical perspectives, diagnostic and therapeutic pearls, and includes a must-know summary, additional reading suggestions and future research directions. Flowcharts, decision-making guides, summary tables, graphics and clinical photographs help to maximize the learning experience and to ensure readers retain what they?ve learned. The book fills a unique niche area for many specialties dedicated to critical care of polytrauma patients and to their management before and beyond intensive care.

1 Historic perspective and relevant evolutionary landmarks in trauma care.- 2 The definition of postinjury Multiple Organ Failure.- 3 The pathomechanism of postinjury MOF.- 4 Genomic considerations related to postinjury MOF.- 5 The epidemiology of postinjury MOF.- 6 The relevance of traumatic shock and its treatment on the epidemiology of MOF.- 7 The relevance of the timing of surgical interventions.- 8 The population at risk, predictors of MOF.- 9 Postinjury MOF with and without infection.- 10 The principles of treatment, modern therapeutic targets.- 11 Central nervous system.- 12 Respiratory failure.- 13 Cardiac failure.- 14 Liver failure.- 15 Gastrointestinal failure, clinical presentations and treatment.- 16 Kidney failure.- 17 Bone marrow failure.- 18 MOF management in low resource settings.- 19 MOF in pregnancy and its relevance to Eclampsia.- 20 MOF in paediatric patients.- 21 Summary of randomised controlled trials with significant effect on MOF outcomes.- 22 Iatrogenic causes leading to MOF.- 23 Short term outcomes, what has changed during the last 40 years?.- 24 Long term outcomes and functional outcomes.- 25 Future directions.

Zsolt J. Balogh is a trauma and orthopaedic trauma surgeon with PhD in postinjury multiple organ failure. He is the Director of Trauma Services for John Hunter Hospital and Hunter New England Health, and the Professor of Surgery and Traumatology at the University of Newcastle, Australia. Professor Balogh’s main clinical and scientific interests are polytrauma care, traumatic shock and resuscitation, inflammatory response and regeneration after severe injury, pelvic/acetabular fractures, major orthopaedic trauma.
His more than 250 peer-reviewed scientific articles had over 20,000 citations. He is the convener of the Master of Traumatology postgraduate program and is leading an established clinical and basic science research program (PhD, Master and Honours). He contributes to numerous peer-reviewed scientific journals as editor, editorial board member. Professor Balogh holds leadership roles in several national and international scientific societies and research advisory boards.

Federico Coccolini is currently working as a general, emergency and trauma surgeon at the General, Emergency and Trauma Surgery Dept. of Bufalini Hospital in Cesena (Italy). His main fields of interest are emergency surgery, trauma surgery, trauma patient management, as well as emergency and trauma system organization and implementation, and abdominal surgery.  He has published widely (more than  100 papers) and has written several book chapters, most of them as first author.  i He is the main investigator of IROA (International Register of Open Abdomen), the widest multicenter cohort study on open abdomen patients ever performed, which is recruiting hundreds of patients from all around the world.

Andrew W. Kirkpatrick is a Professor in both the Departments of Surgery and Critical Care Medicine at the Foothills Medical Centre of the University of Calgary,and the former Medical Director of Regional Trauma Services. Dr

Covers all the myriad aspects of MOF in a unique book encompassing the causes, effects and treatment of post-injury MOF

Addresses the most common cause of death and the reason for the greatest hospital resource utilisation

Includes graphics, guides and figures that help readers understand prevention of post-injury MOF