Metabolites as Signals in Immunity and Inflammation

Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology. These changes occur thanks to breakthrough experiments in basic research, and with the help of new technologies that allow for the testing of immunology hypotheses. In recent years, a substantial number of findings have been made around immunometabolism. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

1. Intro chapter: broad intro2. Host-microbe interactions and the role of immunometabolism 3. Immunometabolism and human diseases4. Cell Death and Metabolism5. Oncology and Metabolism6. Cardiovascular System and Metabolism7. Innate Immunity and Metabolism8. Adaptive Immunity and Metabolism9. Autoimmunity and Metabolism10. Epigenetics and Innate Memory Metabolism11. Diabetes, Obesity, and Metabolism12. Metabolism as a Portal to New Therapeutics

Dr. Zbigniew Zaslona?currently?serves as?Director of Biology?at OncoArendi. He?obtained?his PhD in 2010 at the University of Giessen and the Marburg Lung Center in Germany, studying the mechanisms that modulate innate immunity in the context of pneumonia.?He then undertook a?postdoctoral fellowship at the University of Michigan in the USA, where he focused on pharmacological studies of GPCR receptors, in particular lipid mediators of inflammation.?From?2015?to October 2020, he?was?a research fellow at Trinity College Dublin (Ireland) in the Department of Biochemistry and Immunology, as well as?a Senior Investigator at the UK?biotechnology company?Sitryx?(which in March 2020 entered into a?$1?bln?collaboration and license?agreementacquired by Lillywith?Eli Lilly), where he was responsible for anti-inflammatory drug development programs. Dr. Zaslona is a recognized international expert in the field of inflammatory processes and lung?diseases and?is?repeatedly invited to lecture at?leading?international scientific conferences.
Tristram Ryan is currently undertaking his PhD in the School of Biochemistry and Immunology in Trinity College Dublin, Ireland, in the laboratory of Professor Luke O’Neill. He is studying the role of immunomodulatory drugs in the treatment of inflammation-driven coagulation, termed immunothrombosis, which occurs in conditions such as sepsis and disseminated intravascular coagulation. Tristram is a science enthusiast involved in public engagement and the dissemination of scientific results. He has presented his work at international conferences and as Chairperson of the Trinity College Biochemical Society, organized and hosted a multidisciplinary series of seminars involving scientific leaders from around the world.
Professor Luke O’Neill FRS is the Chair of Biochemistry and Immunology (1960) at Trinity College Dublin, Ireland. He completed his PhD in Pharmacology at the University of London, UK. The O’Neill laboratory has made significant