Lavoisier S.A.S.
14 rue de Provigny
94236 Cachan cedex
FRANCE

Heures d'ouverture 08h30-12h30/13h30-17h30
Tél.: +33 (0)1 47 40 67 00
Fax: +33 (0)1 47 40 67 02


Url canonique : www.lavoisier.fr/livre/documentation/a-history-of-genomics-across-species-communities-and-projects/descriptif_4716639
Url courte ou permalien : www.lavoisier.fr/livre/notice.asp?ouvrage=4716639

A History of Genomics across Species, Communities and Projects, 1st ed. 2023 Medicine and Biomedical Sciences in Modern History Series

Langue : Anglais

Auteurs :

Couverture de l’ouvrage A History of Genomics across Species, Communities and Projects
This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. 

Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production. 


Chapter 1. Introduction
Part I. The Diversity of Genomics
Chapter 2. Distributed and Concentrated Strategies in the Sequencing of the Yeast Genome
Chapter 3. The Human Genome Project(s)
Part II. Communities and Reference Genomes
Chapter 4. The Funnelling Effect of the Sanger Institute
Chapter 5. The Pig Community and Their Reference Genome
Part III. Contextualising and Enhancing Reference Genomes
Chapter 6. Making Reference Genomes Useful: Annotation
Chapter 7. Improving and Going Beyond Reference Genomes
Chapter 8. Conclusion

Miguel García-Sancho is a Senior Lecturer at the University of Edinburgh in the UK. He led the project ‘TRANSGENE: Medical Translation in the History of Modern Genomics’, with funding from the European Research Council.

James Lowe is a Senior Research Fellow at the University of Edinburgh in the UK. He is a historian and philosopher of biology who worked on the European Research Council-funded project ‘TRANSGENE: Medical Translation in the History of Modern Genomics’.


This book is open access, which means that you have free and unlimited access

Examines the history of genomics in a unique way, due to its wide chronological timeframe and multispecies approach

Critically reinterprets the ‘translational gap’ between sequence data and their potential uses

Highlights the significance of scientific communities that were eclipsed by the Human Genome Project

Date de parution :

Ouvrage de 380 p.

14.8x21 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 42,19 €

Ajouter au panier

Date de parution :

Ouvrage de 380 p.

14.8x21 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 52,74 €

Ajouter au panier